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Quantitative analysis of homo- and heterodimerization of muscarinic acetylcholine receptors in live cells
(American Society for Biochemistry and Molecular Biology, 2006-03)
Although previous pharmacological and biochemical data support the notion that muscarinic acetylcholine receptors (mAChR) form homo- and heterodimers, the existence of mAChR oligomers in live cells is still a matter of ...
A necessary connection: cholesterol and nicotinic receptors
(Sociedad Argentina de Biofísica, 2019)
It is known that the muscle nicotinic acetylcholine receptor (nAChR) is highly influenced by its lipid environment. It is present in high-density clusters in the muscle cell membrane where it localizes mainly in liquid-ordered ...
The position of the double bond in monounsaturated free fatty acids is essential for the inhibition of the nicotinic acetylcholine receptor
(Elsevier B.V., 2012)
Abstract: Free fatty acids (FFAs) are non-competitive antagonists of the nicotinic acetylcholine receptor (AChR). Their site of action is supposedly located at the lipid-AChR interface. To elucidate the mechanism involved ...
Evaluation of benzyltetrahydroisoquinolines as ligands for neuronal nicotinic acetylcholine receptors
(Nature Publishing Group, 2005-06-27)
1 Effects of derivatives of coclaurine (C), which mimic the ‘eastern’ or the nonquaternary halves of
the alkaloids tetrandrine or d-tubocurarine, respectively, both of which are inhibitors of nicotinic
acetylcholine ...
Autoimmune attack of the neuromuscular junction in myasthenia gravis : nicotinic acetylcholine receptors and other targets
(American Chemical Society, 2019)
Abstract: The nicotinic acetylcholine receptor (nAChR) family, the archetype member of the
pentameric ligand-gated ion channels, is ubiquitously distributed in the central and
peripheral nervous systems and its members ...
Caracterización farmacológica y funcional de la subunidad a9a10 del receptor nicotínico de la célula cromafín de la médula de la rata
(Universidad Nacional Mayor de San MarcosPE, 2007)
La reciente identificación de las subunidades nicotínicas a9 y a10 en células sensoriales del aparato auditivo y en neuronas de los ganglios raquídeos, motivaron a investigar la posible expresión de estas subunidades en ...
An ER-resident membrane protein complex regulates nicotinic acetylcholine receptor subunit composition at the synapse
(Nature Publishing Group, 2009-07)
Nicotinic acetylcholine receptors (nAChRs) mediate fast excitatory neurotransmission in neurons and muscles. To identify nAChR accessory proteins, which may regulate their expression or function, we performed tandem affinity ...
Ric-3 chaperone-mediated stable cell-surface expression of the neuronal α7 nicotinic acetylcholine receptor in mammalian cells
(Nature Publishing Group, 2009-06)
Aim: Studies of the α7-type neuronal nicotinic acetylcholine receptor (AChR), one of the receptor forms involved in many physiologically relevant processes in the central nervous system, have been hampered by the inability ...