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Effect of the metal ion on the anti T. cruzi activity and mechanism of action of 5-nitrofuryl-containing thiosemicarbazone metal complexes
(Wiley-VCH Verlag, 2014)
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a major health problem worldwide. In this work, we report the development of palladium and platinum metal complexes with 5-nitrofuryl-containing ...
Rhenium(I) tricarbonyl compounds of bioactive thiosemicarbazones: Synthesis, characterization and activity against Trypanosoma cruzi
(2017)
American Trypanosomiasis is a chronic infection discovered and described in 1909 by the Brazilian scientist Carlos Chagas. It is caused by the protozoan parasite Trypanosoma cruzi. Although it affects about 10 million ...
Potential Mechanism of the Anti-trypanosomal Activity of Organoruthenium Complexes with Bioactive Thiosemicarbazones
(Springer, 2013)
In the search for new metal-based drugs against
diseases produced by trypanosomatid parasites, four
organoruthenium(II) compounds [Ru2(p-cymene)2(L)2]
X2, where L are bioactive 5-nitrofuryl-containing
thiosemicarbazones ...
Novel ruthenium(II) cyclopentadienyl thiosemicarbazone compounds with antiproliferative activity on pathogenic trypanosomatid parasites
(2015)
Searching for new prospective antitrypanosomal agents, three novel Ru(II)-cyclopentadienyl compounds, [Ru(eta(5)-C5H5)(PPh3)L], with HL = bioactive 5-nitrofuryl containing thiosemicarbazones were synthesized and characterized ...
Estudio fisicoquímico y biológico de complejos metálicos de platino y paladio con ligantes bioactivos contra Trypanosoma cruzi
(Universidad de Chile, 2020)
La tripanosomiasis americana o enfermedad de Chagas, provocada por
Trypanosoma cruzi, presenta un problema de salud pública en América Latina,
abarcando alrededor de veintiún países. El proceso de globalización ha llevado ...
Novel ruthenium(II) cyclopentadienyl thiosemicarbazone compounds with antiproliferative activity on pathogenic trypanosomatid parasites
(Elsevier, 2015)
Searching for new prospective antitrypanosomal agents, three novel Ru(II)-cyclopentadienyl compounds, [Ru(eta(5)-C5H5)(PPh3)L], with HL = bioactive 5-nitrofuryl containing thiosemicarbazones were synthesized and characterized ...
Water-Soluble Ruthenium Complexes Bearing Activity Against Protozoan Parasites
(Springer, 2014)
Parasitic illnesses are major causes of human disease
and misery worldwide. Among them, both amebiasis and
Chagas disease, caused by the protozoan parasites, Entamoeba
histolytica and Trypanosoma cruzi, are responsible ...
Potent 5-nitrofuran derivatives inhibitors of Trypanosoma cruzi growth: Electrochemical, spectroscopic and biological studies
(2011)
Cyclic voltammetry and electron spin resonance techniques were used in the investigation of several potential antiprotozoal containing thiosemicarbazone and carbamate nitrofurans. In the electrochemical behaviour, a ...
1,2,4-Triazine N-oxide derivatives: Studies as potential hypoxic cytotoxins. Part III
(WILEY-V C H VERLAG GMBH, 2004-05)
New 5-(2-arylethenyl)-1,2,4-triazine N-oxide and N,N'-dioxide derivatives were synthesized in order to obtain compounds as selective hypoxic cell cytotoxins. The desired products were obtained when the 5-methyl heterocycle ...