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NLR family pyrin domain containing 3 (NLRP3) and caspase 1 (CASP1) modulation by intracellular Cl– concentration
(Wiley Blackwell Publishing, Inc, 2021-08)
The impairment of the cystic fibrosis transmembrane conductance regulator (CFTR) activity induces intracellular chloride (Cl–) accumulation. The anion Cl–, acting as a second messenger, stimulates the secretion of ...
NLR family pyrin domain containing 3 (NLRP3) and caspase 1 (CASP1) modulation by intracellular Cl– concentration
(Wiley-Blackwell, 2021)
Abstract:
The impairment of the cystic fibrosis transmembrane conductance regulator (CFTR) activity induces intracellular chloride (Cl–
) accumulation. The anion Cl–
, acting as a second
messenger, stimulates the ...
Determinants of cofactor specificity for the glucose-6-phosphate dehydrogenase from Escherichia coli: Simulation, kinetics and evolutionary studies
(Public Library of Science, 2016-03)
Glucose 6-Phosphate Dehydrogenases (G6PDHs) from different sources show varying specificities towards NAD+ and NADP+ as cofactors. However, it is not known to what extent structural determinants of cofactor preference are ...
Elucidação estrutural da especificidade por substratos de enzimas da biossíntese de aminoglicosídeos e marginolactonas
(Universidade Estadual Paulista (Unesp), 2020-06-26)
Os produtos naturais desempenham um papel importante no desenvolvimento de medicamentos e parte desse sucesso está relacionado com a diversidade química e estrutural apresentadas pelos compostos dotados de relevância ...
Molecular modulation of human α7 nicotinic receptor by amyloid-β peptides
(Frontiers Media S.A., 2019-02-08)
Amyloid β peptide (Aβ) is a key player in the development of Alzheimer’s disease (AD). It is the primary component of senile plaques in AD patients and is also found in soluble forms. Cholinergic activity mediated by α7 ...
Wilson-Fisher fixed points for any dimension
(American Physical Society, 2019-12)
The critical behavior of a nonlocal scalar field theory is studied. This theory has a nonlocal quartic interaction term which involves a power-β of the Laplacian. The power-β is tuned so as to make that interaction marginal ...
Islet neogenesis-associated protein pentadecapeptide (INGAP-PP): Mechanisms involved in its effect upon β-cell mass and function
(Elsevier Science, 2009-10)
The effect of islet neogenesis-associated protein pentadecapeptide (INGAP-PP) administration to normal male hamsters upon serum glucose and triglyceride levels, β-cell mass and function was studied. INGAP-PP (500 μg) or ...
Comments on two-loop Kac-Moody algebras
(Elsevier B.V., 2014)