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Activation of D1/5 Dopamine Receptors in the Dorsal Medial Prefrontal Cortex Promotes Incubated-Like Aversive Responses
(Frontiers Media S.A., 2017-10)
It is well established that neurons of the mammalian medial prefrontal cortex (mPFC) modulate different behavioral outputs, including several memory types. This behavioral modulation is, at least in part, under the control ...
Drogadição: a estimulação tátil recupera aspectos moleculares e comportamentais associados à recaìda por anfetamina em ratos adultos
(Universidade Federal de Santa MariaBrasilFarmacologiaUFSMPrograma de Pós-Graduação em FarmacologiaCentro de Ciências da Saúde, 2022-02-16)
Drug addiction is a chronic neuropsychiatric disorder characterized by the development of dependence, compulsion and frequent episodes of relapse, as available treatments are ineffective to prevent such a situation. ...
Modulação dopaminérgica e glutamatérgica na recaída por morfina em ratos: influência da dieta e de fármacos nanoparticulados
(Universidade Federal de Santa MariaBrasilFarmacologiaUFSMPrograma de Pós-Graduação em FarmacologiaCentro de Ciências da Saúde, 2021-09-30)
Morphine, in addition to being an analgesic drug, also has a high additive potential related to neuroadaptations of the dopaminergic and glutamatergic pathways, in addition to the increase in oxidative events in the ...
New Roles for the Neuropeptide Angiotensin II: Stress and Drug Abuse
(Nova Science Publishers, 2012)
Angiotensin II (Ang II) is known as a peripheral hormone involved in the control of blood pressure and fluid homeostasis. The study and characterization of Ang II and its receptors in the brain has opened a new vision of ...
Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: Effects on ethanol drinking
(Pergamon-Elsevier Science Ltd, 2005-05)
Dopamine (DA) signals are transmitted via specific receptors including the D2 receptors (D2R). Previous studies have shown that D2R upregulation in the nucleus accumbens (NAc) attenuated alcohol consumption. We hypothesized ...
An enantiomeric study of salsolinol involvement in ethanol brain reinforcing effect, via the activation of the Gi pathway of µ-opioid receptorsAn enantiómeric study of salsolinol involvement in ethanol brain reinforcing effect, via the activatión of the gi pathway of µ-opióid receptors
(2018)
The reinforcing effect of ethanol is a major contributor to ethanol dependence. The formation of acetaldehyde, the first ethanol metabolite, is required for ethanol to be reinforcing, by activating dopaminergic neurons in ...
Nicotine-induced molecular alterations are modulated by GABAB receptor activity
(Wiley Blackwell Publishing, Inc, 2018-01)
It has been demonstrated that GABAB receptors modulate nicotine (NIC) reward effect; nevertheless, the mechanism implicated is not well known. In this regard, we evaluated the involvement of GABAB receptors on the behavioral, ...
Schizophrenia-like dopamine release abnormalities in a mouse model of NMDA receptor hypofunction
(Oxford University Press, 2019-01)
Amphetamine-induced augmentation of striatal dopamine and its blunted release in prefrontal cortex (PFC) is a hallmark of schizophrenia pathophysiology. Although N-methyl-D-aspartate receptor (NMDAR) hypofunction is also ...
Epigenetic Dysregulation of Dopaminergic System by Maternal Cafeteria Diet During Early Postnatal Development
(Pergamon-Elsevier Science Ltd, 2019-11)
Dopamine is a neurotransmitter crucial for motor, motivational, and reward-related functions. Our aim was to determine the effect of a palatable maternal diet on the transcriptional regulation of dopaminergic-related genes ...
Pre- and postnatal alcohol exposure delays, in female but not in male rats, the extinction of an auditory fear conditioned memory and increases alcohol consumption
(John Wiley & Sons Inc, 2020-05)
Repeated exposure to alcohol increases retrieval of fear-conditioned memories, which facilitates, among other factors, the emergence of post-traumatic stress disorder (PTSD). Individuals with PTSD are more likely to develop ...