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Mostrando ítems 321-330 de 346
Prospecção dos inibidores de fosfolipases A2 das classes alfa e gama (PLI e PLI) endógenos no plasma de serpentes Crotalidae brasileiras: caracterização molecular e propriedades biológicas
(Universidade Federal de Minas GeraisUFMG, 2008-09-08)
The presence of phospholipase A2 (PLA2) inhibitors in the blood plasma of snakes has been reported by several authors. These inhibitors are, presently, classified in three structural classes named alfa, beta and gamma. ...
Neutralization of snake venom phospholipase A(2) toxins by aqueous extract of Casearia sylvestris (Flacourtiaceae) in mouse neuromuscular preparation
(Elsevier B.V., 2007-07-25)
Aqueous extract of Casearia sylvestris (Flacourtiaceae) has been shown to inhibit enzymatic and biological properties of some Bothrops and Crotalus venoms and their purified phospholipase A(2) (PLA(2)) toxins. In this work ...
Neutralization of snake venom phospholipase A(2) toxins by aqueous extract of Casearia sylvestris (Flacourtiaceae) in mouse neuromuscular preparation
(Elsevier B.V., 2007-07-25)
Aqueous extract of Casearia sylvestris (Flacourtiaceae) has been shown to inhibit enzymatic and biological properties of some Bothrops and Crotalus venoms and their purified phospholipase A(2) (PLA(2)) toxins. In this work ...
Structural evidence for a fatty acid-independent myotoxic mechanism for a phospholipase A2-like toxin
(2018-03-01)
The myotoxic mechanism for PLA2-like toxins has been proposed recently to be initiated by an allosteric change induced by a fatty acid binding to the protein, leading to the alignment of the membrane docking site (MDoS) ...
Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920)
(2019)
The World Health Organization recently listed snakebite envenoming as a Neglected Tropical Disease,
proposing strategies to significantly reduce the global burden of this complex pathology by 2030. In
this context, ...
Reatividade cruzada de anticorpos policlonais IgY anti-BnSP-7 com fosfolipases (PLA2s) de diferentes peçonhas ofídicas e predição in silico de epítopos de células B
(Universidade Federal de UberlândiaBrasilBiotecnologia, 2019)
Neutralização de atividades biológicas das peçonhas de serpentes botrópicas pelo extrato aquoso e compostos isolados de Schizolobium parahyba (FABACEAE)
(Universidade Federal de UberlândiaBRPrograma de Pós-graduação em Genética e BioquímicaCiências BiológicasUFU, 2016)