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c-Abl tyrosine kinase down-regulation as target for memory improvement in Alzheimer's disease
(2023)
BackgroundGrowing evidence suggests that the non-receptor tyrosine kinase, c-Abl, plays a significant role in the pathogenesis of Alzheimer's disease (AD). Here, we analyzed the effect of c-Abl on the cognitive performance ...
c-Abl tyrosine kinase down-regulation as target for memory improvement in Alzheimer's disease
(Wiley, 2023)
BackgroundGrowing evidence suggests that the non-receptor tyrosine kinase, c-Abl, plays a significant role in the pathogenesis of Alzheimer's disease (AD). Here, we analyzed the effect of c-Abl on the cognitive performance ...
Conformation-Independent QSAR on c-Src Tyrosine Kinase Inhibitors
(Elsevier, 2014-03)
The main idea of this work was to find predictive quantitative structure–activity relationships (QSAR) for a wide set of c-Src tyrosine kinase inhibitors, by means of resorting to a conformation-independent representation ...
Activation of spleen tyrosine kinase (Syk) at fertilization in Rhinella arenarum eggs
(U B C Press, 2014-12)
Recently, we have provided evidence for the involvement of a cytosolic tyrosine–phosphorylatable 70 kDa oocyte protein in Rhinella arenarum (Anura: Bufonidae) fertilization. The aim of the present work was to characterize ...
Imatinib derivatives as inhibitors of K562 cells in chronic myeloid leukemia
(Springer Verlag (Germany), 2018)
Nitric oxide and cGMP activate the Ras-MAP kinase pathway-stimulating protein tyrosine phosphorylation in rabbit aortic endothelial cells
(Elsevier B.V., 2003-08-15)
The free radical nitric oxide is a very effective signal transducer, stimulating the enzyme guanylyl cyclase, the oncoprotein p21Ras, and protein tyrosine phosphorylation. in the present study using rabbit aortic endothelial ...
Importance of monitoring and early switch to second generation tyrosine kinase inhibitors for the prognosis of patients with chronic myeloid leukemia with imatinib resistance or intolerance
(Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea, 2011)
Imatinib mesylate was the first BCR-ABL-target agent approved for the treatment of chronic myeloid leukemia. Although most patients respond well to imatinib therapy, the literature shows that one third develops resistance ...
Activation of protein tyrosine kinase: A possible requirement for fixed-bacteria and lipopolysaccharide-induced increase in human natural killer cell activity
(1996)
Preincubation of peripheral blood lymphocytes (PBL) from drug-free, healthy volunteers with either the protein tyrosine kinase inhibitor genistein (GNT, n = 10, final concentration 200 μM) or the protein kinase A activator ...
Current Patient Management of Chronic Myeloid Leukemia in Latin America A Study by the Latin American Leukemia Net (LALNET)
(JOHN WILEY & SONS INC, 2010)
BACKGROUND: Treatment recommendations have been developed for management of patients with chronic myeloid leukemia (CML). METHODS: A 30-item multiple-choice questionnaire was administered to 435 hematologists and ...