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Síntese e avaliação farmacológica de 7-amino-espiro[cromeno[4,3-b]quinolina-6,1’-cicloalcanos] e derivados
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2017)
The present thesis describes the synthesis and pharmacological evaluation of new tacrine structural analogues, as well as N-derivation reactions and C-C and C-N coupling on these compounds. By this way, a series of ...
Effects of amphetamine on the plus-maze discriminative avoidance task in mice
(Springer, 2002-02-01)
Rationale: the contradictory amphetamine effects on memory could be due to different protocols of amphetamine administration or the well-known anxiogenic effect of the drug. Objective: the effects of different protocols ...
Caracterização da atividade da enzima acetilcolinesterase de veneno de bungarus sindanus: estudos comparativos
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2008-03-10)
Acetylcholinesterase (AChE) belongs to a distinct family of serine hydrolases and is found in both synaptic and non-synaptic locations. At the synapses, it plays a major role
in the hydrolysis of the neurotransmitter ...
Efeitos pré e pós sinápticos dos inibidores da acetilcolinesterase na neurotransmissão em musculatura lisa.
(Universidade Federal de São Paulo (UNIFESP), 2010-11-24)
Justification: The present work considers the effects of new inhibitors of acetylcholinesterase (AChE) on the reactivity and neurotransmission in rats and mice. The new anticholinesterase compounds, ITH12118 and ITH12117, ...
Complexos do tipo cis-[Ru(L-phen)2(apy)2]2+ com interesse no tratamento de Mal de Alzheimer: propriedades físico-químicas e estudos de inibição da Acetilcolina Esterase
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Química - PPGQ, 2011-04-15)
The photochemical and photophysical properties of the cis-[Ru(phen)2(4apy)2]2+ complex where 4apy= 4-aminopyridine are reported. In this work the complexes are thermically stable throughout the course of many hours in ...
Anti-dementia medications: current prescriptions in clinical practice and new agents in progress
(2015)
Almost three decades after the publication of the first clinical studies with tacrine, the pharmacological treatment of Alzheimer's disease (AD) remains a challenge. Randomized clinical trials have yielded evidence of ...