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Mostrando ítems 21-30 de 499
2,4-dihydroxy benzaldehyde derived Schiff bases as small molecule Hsp90 inhibitors: rational identification of a new anticancer lead
(Elsevier Science, 2015-04)
Hsp90 is a molecular chaperone that heals diverse array of biomolecules ranging from multiple oncogenic proteins to the ones responsible for development of resistance to chemotherapeutic agents. Moreover they are over-expressed ...
The implementation of NMR techniques for measuring interactions between small organic molecules/inhibitors and enzyme Acetylcholinesterase: a step towards Alzheimer´s control
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2015-05-21)
The inhibition of the acetylcholinesterase (AChE) might be an excellent therapy in controlling Alzheimer’s disease as stated by the cholinergic hypothesis. In this context, the inhibitors of AChE, are of medical and ...
Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic
(ELIFE SCIENCES PUBLICATIONS, 2015-05)
Two ER membrane-resident transmembrane kinases, IRE1 and PERK, function as stress sensors in the unfolded protein response. IRE1 also has an endoribonuclease activity, which initiates a non-conventional mRNA splicing ...
In silico identification of noncompetitive inhibitors targeting an uncharacterized allosteric site of falcipain-2
(2021-01-01)
Falcipain-2 (FP-2) is a Plasmodium falciparum hemoglobinase widely targeted in the search for antimalarials. FP-2 can be allosterically modulated by various noncompetitive inhibitors that have been serendipitously identified. ...
Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation
(2017-12-28)
Three series of biarylpyrazole imidazole and triazoles are described, which vary in the linker between the biaryl pyrazole and imidazole/triazole group. The imidazole and triazole series with the short -CH2- linker displayed ...