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Structure of the lectin mannose 6-phosphate receptor homology (MRH) domain of glucosidase II an enzyme that regulates glycoprotein folding quality control in the endoplasmic reticulum
(American Society for Biochemistry and Molecular Biology, 2013-06)
Here we report for the first time the three-dimensional structure of a mannose 6-phosphate receptor homology (MRH) domain present in a protein with enzymatic activity, glucosidase II (GII). GII is involved in glycoprotein ...
Structure of the Lectin MRH Domain of Glucosidase II, an Enzyme that Regulates Glycoprotein Folding Quality Control in the Endoplasmic Reticulum
(American Society For Biochemistry And Molecular Biology, 2013-04-05)
Here we report for the first time the three-dimensional structure of a mannose 6-phosphate receptor homology (MRH) domain present in a protein with enzymatic activity, glucosidase II (GII). GII is involved in glycoprotein ...
AtUTr1, a UDP-glucose/UDP-galactose transporter from Arabidopsis thaliana, is located in the endoplasmic reticulum and up-regulated by the unfolded protein response
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2006-04-07)
The folding of glycoproteins in the endoplasmic reticulum (ER) depends on a quality control mechanism mediated by the calnexin/calreticulin cycle. During this process, continuous glucose trimming and UDP-glucose-dependent ...
The ER glycoprotein folding sensor UDP-Glc: glycoprotein glucosyltransferase is broadly expressed in C. elegans hermaphrodite
(Caltech Library, 2020-08)
The endoplasmic reticulum (ER) uses an elaborate system called the ER quality control (QC) to monitor the proper folding of newly synthesized glycoproteins. The QC allows cells to differentiate between properly folded and ...
XBP-1 and UPRosome: mastering secretory cell function
(2008)
A unique feature of secretory cells is the proliferation of the endoplasmic reticulum (ER) and Golgi network. The high demand imposed by protein synthesis and folding in secretory cells constitutes an endogenous source of ...
Targeting of the unfolded protein response (UPR) as therapy for Parkinson's disease
(Wiley-Blackwell Publishing Ltd, 2019)
Parkinson's disease is the second most common neurodegenerative disorder, leading to the progressive decline of motor control due to the loss of dopaminergic neurons in the substantia nigra pars compacta. At the molecular ...
The evolutionary history of calreticulin and calnexin genes in green plants
(SpringerDordrechtHolanda, 2011)
Glucosidase II and MRH-Domain Containing Proteins in the Secretory Pathway
(Bentham Science Publishers, 2015-01)
N-glycosylation in the endoplasmic reticulum (ER) consists of the transfer of a preassembled glycan conserved among species (Glc3Man9GlcNAc2) from a lipid donor to a consensus sequence within a nascent protein that is ...
Chaperone mediated autophagy contributes to the newly synthesized histones H3 and H4 quality control
(2022)
Although there are several pathways to ensure that proteins are folded properly in the cell, little is known about the molecular mechanisms regulating histone folding and proteostasis. In this work, we identified that ...