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Mostrando ítems 21-30 de 33
Signal Transmission in Escherichia coli Cyclic AMP Receptor Protein for Survival in Extreme Acidic Conditions
(American Chemical Society, 2021-10-12)
During the life cycle of enteric bacterium Escherichia coli, it encounters a wide spectrum of pH changes. The asymmetric dimer of the cAMP receptor protein, CRP, plays a key role in regulating the expressions of genes and ...
Allosteric Pathways In The Pparγ 3-rxrα Nuclear Receptor Complex
(Nature Publishing Group, 2016)
Unmasking Determinants of Specificity in the Human Kinome
(Cell Press, 2015-09)
Protein kinases control cellular responses to environmental cues by swift and accurate signal processing. Breakdowns in this high-fidelity capability are a driving force in cancer and other diseases. Thus, our limited ...
Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase
(Cell Press, 2016-10)
Allostery is a phenomenon observed in many proteins where binding of a macromolecular partner or a small-molecule ligand at one location leads to specific perturbations at a site not in direct contact with the region where ...
Correlated Inter-Domain Motions in Adenylate Kinase
(Public Library Of Science, 2014-07)
Correlated inter-domain motions in proteins can mediate fundamental biochemical processes such as signal transduction and allostery. Here we characterize at structural level the inter-domain coupling in a multidomain enzyme, ...
Dinâmica estrutural da proteína adaptadora Grb2, seu domínio SH2 e a interação com cumarina por ressonância magnética nuclear e fluorescência
(Universidade Estadual Paulista (Unesp), 2019-04-12)
As células são submetidas a um constante e preciso controle de sobrevivência, crescimento, diferenciação e apoptose. Durante o processo de proliferação celular, estas também estão sujeitas a erros que podem gerar perda de ...
Estudo da dinâmica e caracterização estrutural da interface proteica em Quimeras Xilanase-XBP por simulação molecular
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM QUÍMICA, 2019-07-17)
In the field of molecular biology and biotechnology, proteins owning two or more combined
activities, coupled with an appropriate structural stability, have been widely applied. A few
years ago three hybrid enzymes / ...
Functional studies of the deubiquitinating enzymes USP19, USP4 and UCH-L1
(Universidad del RosarioDoctorado en Ciencias BiomédicasFacultad de Ciencias Naturales y Matemáticas, 2013)
The conjugation of ubiquitin to proteins, known as ubiquitination, has different cellular functions; they include targeting proteins for degradation by the proteasome, regulation of DNA damage repair signaling, membrane ...
S-nitrosoglutathione Inhibits Inducible Nitric Oxide Synthase Upregulation By Redox Posttranslational Modification In Experimental Diabetic Retinopathy
(Association for Research in Vision and Ophthalmology Inc., 2014)