Buscar
Mostrando ítems 21-30 de 141
Papilomavírus humano e a carcinogênse de mucosa oral: avaliação imunohistoquímica das protínas p27, mdm2 E catepsina B
(Universidade Estadual Paulista (UNESP), 2014)
Avaliação da expressão proteica de PTEN, MDM2, P53 e AR em lesões proliferativas da próstata canina
(Universidade Estadual Paulista (Unesp), 2014-07-30)
The canine prostate may spontaneously develop prostatic proliferative lesions, associated with aging, inflammation and hormones, such as: benign prostatic hyperplasia (BPH), proliferative inflammatory atrophy (PIA) and ...
Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on the age of onset of cutaneous melanoma
(Nature Publishing Group, 2012-05)
Melanoma accounts for the majority of deaths from skin cancer. Women tend to be diagnosed at a younger age and have better survival than men. A tumor-host interaction might be responsible for these gender-specific differences. ...
A single synonymous mutation determines the phosphorylation and stability of the nascent protein
(Chinese Academy of Sciences, 2019)
p53 is an intrinsically disordered protein with a large number of post-translational modifications and interacting partners. The hierarchical order and subcellular location of these events are still poorly understood. The ...
Hydrogen bond dynamic propensity studies for protein binding and drug design
(Public Library of Science, 2016-10-28)
We study the dynamic propensity of the backbone hydrogen bonds of the protein MDM2 (the natural regulator of the tumor suppressor p53) in order to determine its binding properties. This approach is fostered by the observation ...
Abnormal cell-cycle expression of the proteins p27, mdm2 and cathepsin B in oral squamous-cell carcinoma infected with human papillomavirus
(Elsevier Gmbh, Urban & Fischer Verlag, 2011-01-01)
Since the role of human papillomavirus (HPV) infection in oral carcinogenesis is still unclear, the purpose of this study was to verify the association between the expression of p27, mdm2 and cathepsin B and by HPV-related ...
Abnormal cell-cycle expression of the proteins p27, mdm2 and cathepsin B in oral squamous-cell carcinoma infected with human papillomavirus
(Elsevier Gmbh, Urban & Fischer Verlag, 2011-01-01)
Since the role of human papillomavirus (HPV) infection in oral carcinogenesis is still unclear, the purpose of this study was to verify the association between the expression of p27, mdm2 and cathepsin B and by HPV-related ...
Papilomavírus humano e a carcinogênse de mucosa oral: avaliação imunohistoquímica das protínas p27, mdm2 E catepsina B
(Universidade Estadual Paulista (Unesp), 2007-06-01)
O mdm2 parece controlar o tráfego da proteína p53 do núcleo-citoplasma enquanto a proteína p27 é um inibidor de CDK que controla a fase G1 para S do ciclo celular. Em contraste, a catepsina B parece induzir um sinal de ...
Papilomavírus humano e a carcinogênse de mucosa oral: avaliação imunohistoquímica das protínas p27, mdm2 E catepsina B
(Universidade Estadual Paulista (Unesp), 2007-06-01)
O mdm2 parece controlar o tráfego da proteína p53 do núcleo-citoplasma enquanto a proteína p27 é um inibidor de CDK que controla a fase G1 para S do ciclo celular. Em contraste, a catepsina B parece induzir um sinal de ...