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Endurance training activates AMP-activated protein kinase, increases expression of uncoupling protein 2 and reduces insulin secretion from rat pancreatic islets
(BIOSCIENTIFICA LTD, 2011)
Endurance exercise is known to enhance peripheral insulin sensitivity and reduce insulin secretion. However, it is unknown whether the latter effect is due to the reduction in plasma substrate availability or alterations ...
Epigenética e câncer gástrico: papel das sirtuínas na oncogênese e sua associação com biomarcadores oxidativos
(Universidade Federal de PernambucoUFPEBrasilPrograma de Pos Graduacao em Biologia Aplicada a Saude, 2019)
Exercise training decreases mitogen-activated protein kinase phosphatase-3 expression and suppresses hepatic gluconeogenesis in obese mice
(Wiley-Blackwell, 2014-03-15)
Key points summaryWhen the hepatic insulin signaling is compromised, there is an inadequate suppression of gluconeogenic pathways, leading the organism to high levels of glucose.Studies with animals with obesity induced ...
Mechanisms Involved in 3 `,5 `-Cyclic Adenosine Monophosphate-Mediated Inhibition of the Ubiquitin-Proteasome System in Skeletal Muscle
(ENDOCRINE SOC, 2009)
Although it is well known that catecholamines inhibit skeletal muscle protein degradation, the molecular underlying mechanism remains unclear. This study was undertaken to investigate the role of beta(2)-adrenoceptors (AR) ...
Mitostasis, Calcium and Free Radicals in Health, Aging and Neurodegeneration
(MDPI, 2021-07)
Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic plasticity. Their functional integrity is ...
Characterization of a multiprotein complex involved in excitation-transcription coupling of skeletal muscle
(Biomed Central, 2016)
Background: Electrical activity regulates the expression of skeletal muscle genes by a process known as “
excitation-transcription” (E-T) coupling. We have demonstrated that release of adenosine 5′-triphosphate (ATP) ...
The Role of Lipotoxicity in Smoke Cardiomyopathy
(Public Library Science, 2015)
Treatment with the synthetic PPARG ligand pioglitazone ameliorates early ovarian alterations induced by dehydroepiandrosterone in prepubertal rats
(Polish Acad Sciences Inst Pharmacology, 2019-02)
Background: Peroxisome proliferator-activated receptor gamma (PPARG) is a nuclear factor that may act on the early development of ovarian follicles and on follicular steroidogenesis. However, the exact mechanism of PPARG ...
Inflammation of the Hypothalamus Leads to Defective Pancreatic Islet Function
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2011)
Type 2 diabetes mellitus results from the complex association of insulin resistance and pancreatic beta-cell failure. Obesity is the main risk factor for type 2 diabetes mellitus, and recent studies have shown that, in ...