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Development of an ionic liquid-based dispersive liquid–liquid microextraction method for the determination of nifurtimox and benznidazole in human plasma
(Elsevier Science, 2013-01)
Dispersive ionic liquid–liquid microextraction combined with liquid chromatography and UV detection was used for the determination of two antichagasic drugs in human plasma: nifurtimox and benznidazole. The effects of ...
Quantification of immunoglobulin G against trypanosoma cruzi in individuals with chronic chagas disease treated with nifurtimox and evaluated in prolonged follow-up
(Korean Society for Parasitology and Tropical Medicine, 2019)
In the indeterminate chronic period of Chagas disease (ChD) the treatment has not been conclusive, because the serological negativization requires many years. This study aims to evaluate the efficacy of nifurtimox (NF) in ...
Effects of buthionine sulfoximine nifurtimox and benznidazole upon trypanothione and metallothionein proteins in Trypanosoma cruzi
(Society of Biology of Chile, 2004)
Proteins rich in sulfhydryl groups, such as metallothionein, are present in several strains of the parasite Trypanosoma cruzi, the etiological agent of Chagas' disease. Metallothionein-like protein concentrations ranged ...
Toxic and therapeutic effects of Nifurtimox and Benznidazol on Trypanosoma cruzi ex vivo infection of human placental chorionic villi explants
(Elsevier, 2014)
Nifurtimox (Nfx) and Benznidazole (Bnz) are the only available drugs in use for the treatment of Chagas
disease. These drugs are recommended but not fully validated in evidence-based medicine and reports
about the ...
Avaliação da Associação do quimioterápico benzonidazol a outros fármacos com ação anti-T. Cruzi no tratamento da doença de chagas experimental
(Sociedade Brasileira de Parasitologia, 2020)
Avaliação da associação do quimioterápico benzonidazol a outros fármacos com ação anti-T. Cruzi no tratamento da Doença de Chagas experimental
(Sociedade Brasileira de Medicina Tropical, 2017)
Effects of buthionine sulfoximine nifurtimox and benznidazole upon trypanothione and metallothionein proteins in Trypanosoma cruzi.
(Sociedad de Biología de Chile, 2004)
Trypanosoma cruzi: In vitro effect of aspirin with nifurtimox and benznidazole
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010)
Nifurtimox and benznidazole are the only active drugs against Trypanosoma cruzi; however, they have limited efficacy and severe side effects. During primoinfection, T cruzi infected macrophages mount an antiparasitic ...
Metodología UV para la determinación de los antichagásicos Nifurtimox y Benznidazol en sangreUV methodology for determination of antichagasic drugs Nifurtimox and Benznidazol in bloodMetodologia UV para a determinação dos antichagásicos Nifurtimox e Benznidazol em sangue
(Federación Bioquímica de la Provincia Buenos Aires, 2011-09)
El Mal de Chagas es una enfermedad parasitaria endémica en América del Sur y Central. Existen dos fármacos disponibles para el tratamiento médico de la enfermedad, el Nifurtimox (Nfx) y el Benznidazol (Bz). No existen ...
Prospective, historically controlled study to evaluate the efficacy and safety of a new paediatric formulation of nifurtimox in children aged 0 to 17 years with chagas disease one year after treatment (Chico)
(Public Library of Science, 2021-07)
Nifurtimox is a recommended treatment for Chagas disease, but data from treated children are limited. We investigated the efficacy, safety and tolerability of nifurtimox administered as divisible, dispersible 30 mg and 120 ...