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Care bundle to reduce readmission in patients with heart failure: a modified Delphi consensus panel in Argentina
(BMJ Publishing Group, 2020-12)
Objectives The aim of this study was to develop consensus among Argentine cardiologists on a care bundle to reduce readmissions of patients with heart failure (HF). Setting Hospitals and cardiology clinics in Argentina ...
Gingival crevicular fluid zinc- and aspartyl-binding protease profile of individuals with moderate/severe atopic dermatitis
(MDPI, 2020)
Atopic dermatitis (AD) is a protease-modulated chronic disorder with heterogenous clinical manifestations which may lead to an imprecise diagnosis. To date, there are no diagnostic protease tests for AD. We explored the ...
A scrutiny of the biochemical pathways from Ang II to Ang-(3-4) in renal basolateral membranes
(Elsevier B.V., 2009-11-27)
In a previous paper we demonstrated that Ang-(3-4) counteracts inhibition of the Ca(2+)-ATPase by Ang II in the basolateral membranes of kidney proximal tubules cells (BLM). We have now investigated the enzymatic routs by ...
Pharmaco-disparities in heart failure: a survey of the affordability of guideline recommended therapy in 10 countries
(Wiley, 2023)
Aims: Heart failure with reduced ejection fraction (HFrEF) is treatable but guideline-directed medical therapy (GDMT) may not be affordable or accessible to people living with the disease. Methods and results: In this ...
Biochemical characterization of the venom of Central American scorpion Didymocentrus krausi Francke, 1978 (Diplocentridae) and its toxic effects in vivo and in vitro
(2019)
non-buthid venoms, for which knowledge is scarce. In this work, we characterized the venom of a Diplocentridae
species, Didymocentrus krausi, a small fossorial scorpion that inhabits the Tropical Dry Forest of Central ...
Imbalance in Renal Vasoactive Enzymes Induced by Mild Hypoxia : Angiotensin-Converting Enzyme Increases While Neutral Endopeptidase Decreases
(2018-12-11)
Chronic hypoxia has been postulated as one of the mechanisms involved in salt-sensitive hypertension and chronic kidney disease (CKD). Kidneys have a critical role in the regulation of arterial blood pressure through ...
Presenilin-1 280Glu-->Ala mutation alters C-terminal APP processing yielding longer abeta peptides: implications for Alzheimer's disease
(Feinstein Institute for Medical Research, 2008-03)
Presenilin (PS) mutations enhance the production of the Abeta42 peptide that is derived from the amyloid precursor protein (APP). The pathway(s) by which the Abeta42 species is preferentially produced has not been elucidated, ...
Efeitos bioquímicos e farmacológicos da fosforilação de componentes do sistema calicreínas-cininas
(Universidade Federal de São Paulo (UNIFESP), 2015-11-25)
Phosphorylated kininogen and some of its fragments containing serine phosphorylated bradykinin ([pS6]-Bk) were found in human serum and plasma by phosphoproteomic approaches. In the present study, we report the kininogenase ...
Estudo da atividade antinociceptiva do peptídeo sintético PnPP-19
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2018-02-23)
The toxin PnTx2-6, isolated from the venom of the spider Phoneutria nigriventer, is very toxic (LD50 = 0.7 μg/mouse) and has been studied as a molecule that improves erectile function. Besides this effect, this toxin induces ...