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Evaluation of the in vitro and in vivo performance of two sustained- release lithium carbonate matrix tablets. Effect of different diets on the bioavailability
(1999)
Two sustained-release (SR) lithium carbonate (Li) matrix tablets, which use a hydrophilic (HP) matrix of hydroxypropylmethylcellulose (Methocel 4K MP) and a lipid (L) matrix of hydrogenated castor oil (Cutina HR) as ...
Small molecules to perform big roles: The search for Parkinson's and Huntington's disease therapeutics
(2023)
Neurological motor disorders (NMDs) such as Parkinson's disease and Huntington's disease are characterized by the accumulation and aggregation of misfolded proteins that trigger cell death of specific neuronal populations ...
Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects
(Frontiers Media S.A., 2020-10-30)
In the golden age of pharmaceutical nanocarriers, we are witnessing a maturation stage of the original concepts and ideas. There is no doubt that nanoformulations are extremely valuable tools for drug delivery applications; ...
How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
(Smart Science & Technology, 2014-02)
Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of ...
Terapia celular alogênica: transplante de fração mononuclear da medula óssea após pré-condicionamento com busulfan e ciclofosfamida em camundongos portadores de Toxoplasma gondii
(Universidade Federal de Santa MariaBRMedicina VeterináriaUFSMPrograma de Pós-Graduação em Medicina Veterinária, 2014-08-08)
The study concerning the lifelong dynamic of undifferentiated cell populations present in the organism expanded the therapeutics frontiers aiming to healing several kinds of wounds and diseases. Different cell populations ...
Functional and structural interaction of (-)-Reboxetine with the human α4β2 nicotinic acetylcholine receptor
(American Society for Pharmacology and Experimental Therapeutics, 2013-01)
The interaction of the selective norepinephrine reuptake inhibitor (-)-reboxetine with the human α4β2 nicotinic acetylcholine receptor (nAChR) in different conformational states was studied by several functional and ...
Phenothiazine molecule provides the basic chemical structure for various classes of pharmacotherapeutic agents
(2006)
The chemical structure of phenothiazine provides a most valuable molecular template for the development of agents able to interact with a wide variety of biological processes. Synthetic phenothiazines (with aliphatic, ...
Chronic Stress and Glucocorticoid Receptor Resistance in Asthma
(Elsevier, 2020-06)
Purpose: Chronic and persistent exposure to negative stress can lead to adverse consequences on health. Particularly, psychosocial factors were found to increase the risk and outcome of respiratory diseases like asthma. ...
Cys-loop receptors in Caenorhabditis elegans as pharmacological drug targets (Simposio)
(Fundación Revista Medicina, 2019)
The free-living nematode Caenorhabditis elegans has emerged as a powerful model for the study of the nervous system and human diseases and as a model for antiparasitic drug discovery. This nematode has also shown promise ...