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The structure of unliganded sterol carrier protein 2 from Yarrowia lipolytica unveils a mechanism for binding site occlusion
(Academic Press Inc Elsevier Science, 2021-03-02)
Isolated or as a part of multidomain proteins, Sterol Carrier Protein 2 (SCP2) exhibits high affinity and broad specificity for different lipidic and hydrophobic compounds. A wealth of structural information on SCP2 domains ...
Molecular dynamics simulations reveal multiple pathways of ligand dissociation from thyroid hormone receptors
(Biophysical SocietyBethesdaEUA, 2005)
Functional analysis of the citrate activator CitO from Enterococcus faecalis implicates a divalent metal in ligand binding
(Frontiers Research Foundation, 2016-02)
The regulator of citrate metabolism, CitO, from Enterococcus faecalis belongs to the FCD family within the GntR superfamily. In the presence of citrate, CitO binds to cis-acting sequences located upstream of the cit promoters ...
On the Denaturation Mechanisms of the Ligand Binding Domain of Thyroid Hormone Receptors
(AMER CHEMICAL SOC, 2010)
The ligand binding domain (LBD) of nuclear hormone receptors adopts a very compact, mostly alpha-helical structure that binds specific ligands with very high affinity. We use circular dichroism spectroscopy and high-temperature ...
On the denaturation mechanisms of the ligand binding domain of thyroid hormone receptors
(American Chemical Society - ACSWashington, DC, 2010-01)
The ligand binding domain (LBD) of nuclear hormone receptors adopts a very compact, mostly α-helical structure that binds specific ligands with very high affinity. We use circular dichroism spectroscopy and high-temperature ...
Molecular Mechanism of Peroxisome Proliferator-Activated Receptor alpha Activation by WY14643: a New Mode of Ligand Recognition and Receptor Stabilization
(Academic Press Ltd- Elsevier Science LtdLondonInglaterra, 2013)
Conformational Diversity Of The Helix 12 Of The Ligand Binding Domain Of Ppar Gamma And Functional Implications
(AMER CHEMICAL SOCWASHINGTON, 2015)
Identification of a new hormone-binding site on the surface of thyroid hormone receptor
(Endocrine SocietyChevy Chase, 2014-04)
Thyroid hormone receptors (TRs) are members of the nuclear receptor superfamily of ligand-activated transcription factors involved in cell differentiation, growth, and homeostasis. Although X-ray structures of many nuclear ...
Low resolution structures of the retinoid X receptor DNA-binding and ligand-binding domains revealed by synchrotron x-ray solution scattering
(The American Society for Biochemistry and Molecular Biology, 2013)
Characterization of fatty acid binding and transfer from ∆98∆, a functional all-β abridged form of IFABP
(Elsevier Science, 2014-12)
Intestinal fatty acid binding protein (IFABP) is an intracellular lipid binding protein whose specific functions within the cell are still uncertain. An abbreviated version of IFABP encompassing residues 29–126, dubbed ...