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Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse cortical cell line
(SOC BIOLGIA CHILE, 2008)
We have previously characterized a number of small molecule organic compounds that prevent the
aggregation of the β-amyloid peptide and its neurotoxicity in hippocampal neuronal cultures. We have now
evaluated the effects ...
Amyloid-B-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the AB peptide. Implications for the pathogenesis of Alzheimer's disease
(2010)
Abstract
The presence of amyloid-β (Aβ) deposits in selected brain regions is a hallmark of Alzheimer's disease (AD). The amyloid deposits have "chaperone molecules" which play critical roles in amyloid ...
Hemichannels Are Required for Amyloid beta-Peptide-Induced Degranulation and Are Activated in Brain Mast Cells of APPswe/PS1dE9 Mice
(2015)
Mast cells (MCs) store an array of proinflammatory mediators in secretory granules that are rapidly released upon activation by diverse conditions including amyloid beta (A beta) peptides. In the present work, we found a ...
TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2007)
Neurotrophins are trophic factors that regulate important neuronal functions. They bind two unrelated receptors, the Trk family of receptor-tyrosine kinases and the p75 neurotrophin receptor (p75). p75 was recently identified ...
Reactive oxygen species released from astrocytes treated with amyloid beta oligomers elicit neuronal calcium signals that decrease phospho-Ser727-STAT3 nuclear content
(Elsevier, 2018)
The transcription factor STAT3 has a crucial role in the development and maintenance of the nervous system. In this work, we treated astrocytes with oligomers of the amyloid beta peptide (A beta Os), which display potent ...
Hepcidin attenuates amyloid beta-induced inflammatory and pro-oxidant responses in astrocytes and microglia
(Wiley, 2017)
Alzheimer's disease (AD) is characterized by extracellular senile plaques, intracellular neurofibrillary tangles, and neuronal death. Aggregated amyloid-beta (A beta) induces inflammation and oxidative stress, which have ...
Hepcidin attenuates amyloid beta-induced inflamatory and pro-oxidant responses in astrocytes and microglia
(2017)
Alzheimer's disease (AD) is characterized by extracellular senile plaques, intracellular neurofibrillary tangles, and neuronal death. Aggregated amyloid-beta (A beta) induces inflammation and oxidative stress, which have ...
beta-Amyloid Causes Depletion of Synaptic Vesicles Leading to Neurotransmission Failure
(2010)
Alzheimer disease is a progressive neurodegenerative brain disorder that leads to major debilitating cognitive deficits. It is believed that the alterations capable of causing brain circuitry dysfunctions have a slow onset ...