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Role of different proteolytic pathways in degradation of muscle protein from streptozotocin-diabetic rats
(1996-08-01)
In vitro rates of overall proteolysis and the activities of four different proteolytic pathways (lysosomal, Ca2+ dependent, ATP dependent, and ATP independent), as well as rates of protein synthesis, were measured in soleus ...
Endurance Training Inhibits Insulin Clearance And Ide Expression In Swiss Mice
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2015)
The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid β peptide: Implications for Alzheimer disease pathogenesis
(American Society for Biochemistry and Molecular Biology, 2008-06)
Insulin-degrading enzyme (IDE) is central to the turnover of insulin and degrades amyloid β (Aβ) in the mammalian brain. Biochemical and genetic data support the notion that IDE may play a role in late onset Alzheimer ...
I-Insulin transfer to mitochondria
(Springer, 2014-10)
The aim of this study was to determine if insulin is transferred to mitoplasts by insulin-degrading enzyme (IDE).Hepatic mitochondria were isolated and controlled by electron microscopy. IDE was obtained from rats muscle ...