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Triheptanoin protects against status epilepticus induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration
(Wiley, 2018)
Triheptanoin, the triglyceride of heptanoate, is anaplerotic (refills deficient tricarboxylic acid cycle intermediates) via the propionyl-CoA carboxylase pathway. It has been shown to be neuroprotective and anticonvulsant ...
Morphological neurite changes induced by porcupine inhibition are rescued by Wnt ligands
(2021)
Abstract
Background
Wnt signaling plays key roles in cellular and physiological processes, including cell proliferation, differentiation and migration during development ...
An oxidative stress-mediated positive-feedback iron uptake loop in neuronal cells
(2002)
Intracellular reactive iron is a source of free radicals and a possible cause of cell damage. In this study, we analyzed the changes in iron homeostasis generated by iron accumulation in neuroblastoma (N2A) cells and ...
Frizzled-1 receptor regulates adult hippocampal neurogenesis.
(2016)
Background: In the adult hippocampus new neurons are continuously generated from neural stem cells (NSCs) present at the subgranular zone of the dentate gyrus. This process is controlled by Wnt signaling, which plays a ...
S-nitrosylation of proteins in hippocampal and cortical neurons in excitotoxicity: differential regulation of NF-kB
(2018)
Cell death by excitotoxicity is a consequence of excessive stimulation of N-methyl-Daspartate
(NMDA) receptors, causing calcium overload and synthesis of nitric oxide.
Hippocampal neurons are selectively sensitive to ...
Interfering of the Reelin/ApoER2/PSD95 Signaling Axis Reactivates Dendritogenesis of Mature Hippocampal Neurons
(2017)
Reelin, an extracellular glycoprotein secreted in embryonic and adult brain, participates in neuronal migration and neuronal plasticity. Extensive evidence shows that reelin via activation of the ApoER2 and VLDLR receptors ...
Interfering of the Reelin/ApoER2/PSD95 Signaling Axis Reactivates Dendritogenesis of Mature Hippocampal Neurons
(2017)
Reelin, an extracellular glycoprotein secreted in embryonic and adult brain, participates in neuronal migration and neuronal plasticity. Extensive evidence shows that reelin via activation of the ApoER2 and VLDLR receptors ...
Tubulin polyglutamylation is a general traffic-control mechanism in hippocampal neurons
(Company of Biologists, 2020)
Neurons are highly complex cells that heavily rely on intracellular transport to distribute a range of functionally essential cargoes within the cell. Post-translational modifications of tubulin are emerging as mechanisms ...