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Testes de biocompatibilidade in vitro de duas formas comerciais do agregado de trióxido mineral
(2005-07-01)
Recently, regular and white mineral trioxide aggregate (MTA) are being used in Dentistry as retrofilling materials. Genotoxicity and cytotoxicity tests form an important part of cancer research and risk assessment of ...
Immune response to cytolethal distending toxin of Aggregatibacter actinomycetemcomitans in periodontitis patients
(WILEY-BLACKWELL, 2010)
Background and Objective: Cytolethal distending toxin (CDT) is a genotoxin produced by Aggregatibacter actinomycetemcomitans. In spite of its association with pathogenesis, little is known about the humoral immune response ...
Profile of micronucleus frequencies and DNA damage in different species of fish in a eutrophic tropical lake
(Sociedade Brasileira de Genética, 2009-01)
Lake Paranoá is a tropical reservoir for the City of Brasilia, which became eutrophic due to inadequate sewage treatment associated with intensive population growth. At present, two wastewater treatment plants are capable ...
Beyond interstrand crosslinks repair: contribution of FANCD2 and other Fanconi Anemia proteins to the replication of DNA
(Elsevier Science, 2018-03)
Biallelic mutations of FANCD2 and other components of the Fanconi Anemia (FA) pathway cause a disease characterized by bone marrow failure, cancer predisposition and a striking sensitivity to agents that induce crosslinks ...
Cell death in response to genotoxic stress and DNA damage:
(Cambridge University Press, 2011)
Cells are subjected to multiple types of stress throughout their life cycle, including starvation, infection, and physical and chemical agents. Stressors cause transient and permanent damage. Transient damage is reflected ...
Nutraceutic Potential of Two Allium Species and Their Distinctive Organosulfur Compounds: A Multi-Assay Evaluation
(Multidisciplinary Digital Publishing Institute, 2019-06-21)
This study aimed to evaluate the biological activities of two Allium species (garlic and onion) as well as diallyl disulphide (DADS) and dipropyl disulphide (DPDS) as their representative bioactive compounds in a multi-assay ...
Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism
(Nature Publishing Group, 2017-08)
The folate-driven one-carbon (1C) cycle is a fundamental metabolic hub in cells that enables the synthesis of nucleotides and amino acids and epigenetic modifications. This cycle might also release formaldehyde, a potent ...
Utilidad de la prueba de micronúcleos y anormalidades nucleares en células exfoliadas de mucosa oral en la evaluación de daño genotóxico y citotóxico [Utility micronucleus test and nuclear abnormalities in exfoliated cells of oral mucosa in the evaluation of genotoxic and cytotoxic damage]
(2013)
Micronucleus are fragments or whole chromosomes that are outside the nucleus during mitosis. Through this study we can evaluate the environmental and occupational the genotoxic effects. This test is widely used because it ...
Utilidad de la prueba de micronúcleos y anormalidades nucleares en células exfoliadas de mucosa oral en la evaluación de daño genotóxico y citotóxico [Utility micronucleus test and nuclear abnormalities in exfoliated cells of oral mucosa in the evaluation of genotoxic and cytotoxic damage]
(2013)
Micronucleus are fragments or whole chromosomes that are outside the nucleus during mitosis. Through this study we can evaluate the environmental and occupational the genotoxic effects. This test is widely used because it ...
Similar polycyclic aromatic hydrocarbon and genotoxicity profiles of atmospheric particulate matter from cities on three different continents
(2020-06-01)
The extractable organic material (EOM) from atmospheric total suspended particles (TSP) contains several organic compounds including non-substituted polycyclic aromatic hydrocarbons (PAHs), alkyl-PAHs, and nitro-PAHs. These ...