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The mediating role of contextual problems and sensation seeking in the association between substance use and mental health in adolescents from northern Chile
(MDPI, 2022)
Substance use is a risk behavior that has been associated with adverse mental health outcomes in adolescence. The aim of this study was to determine the relation between behavioral problems, emotional problems, and substance ...
Stress induces behavioral sensitization, increases nicotine-seeking behavior and leads to a decrease of CREB in the nucleus accumbens
(Pergamon-Elsevier B.V. Ltd, 2012-05-01)
Experimental evidence shows that exposure to stress engenders behavioral sensitization and increases drug-seeking and leads to intense drug taking. However the molecular mechanisms involved in these processes is not well ...
A randomized trial of audio computer and in-person interview to assess HIV risk among drug and alcohol users in Rio De Janeiro, Brazil
(Pergamon-Elsevier Science LTD, 2010)
Anabolic-androgenic steroid treatment induces behavioral disinhibition and downregulation of serotonin receptor messenger RNA in the prefrontal cortex and amygdala of male mice
(WILEY-BLACKWELL, 2009)
Nandrolone is an anabolic-androgenic steroid (AAS) that is highly abused by individuals seeking enhanced physical strength or body appearance. Supraphysiological doses of this synthetic testosterone derivative have been ...
Mecanismos comportamentais e moleculares envolvidos na interação entre as substâncias de abuso e os fatores de risco para o desenvolvimento da dependência
(Universidade Federal de São CarlosBRUFSCarPrograma Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCF, 2013-03-08)
Tobacco and ethanol are the most used drugs in the world and often co-abused. An important issue in the field of drug abuse research is the characterization of risk factors related to increased vulnerability to drug ...
Loss of feedback inhibition via D2 autoreceptors enhances acquisition of cocaine taking and reactivity to drug-paired cues
(Nature Publishing Group, 2015-05)
A prominent aspect of drug addiction is the ability of drug-associated cues to elicit craving and facilitate relapse. Understanding the factors that regulate cue reactivity will be vital for improving treatment of addictive ...
Inhibitory effect of GABAergic drugs in cocaine-induced genital reflexes in paradoxical sleep-deprived male rats
(Elsevier B.V., 2004-06-01)
The aim of this study was to seek whether GABAergic drugs were involved in the action of cocaine on spontaneous genital reflexes (penile erection-PE, and ejaculation-EJ) of paradoxical sleep-deprived (PSD) male rats. After ...