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Impact of participatory design for drug-drug interaction alerts. A comparison study between two interfaces
(IOS Press, 2016-08)
Decision support systems for alert drug-drug interactions have been shown as valid strategy to reduce medical error. Even so the use of these systems has not been as expected, probably due to the lack of a suitable design. ...
Participatory design for drug-drug interaction alerts
(IOS Press, 2015-01)
The utilization of decision support systems, in the point of care, to alert drug-drug interactions has been shown to improve quality of care. Still, the use of these systems has not been as expected, it is believed, because ...
Interaction between DNA and drugs having protonable basic groups: Characterization through affinity constants, drug release kinetics, and conformational changes
(MDPI AG, 2017-03-04)
This paper reports the in vitro characterization of the interaction between the phosphate groups of DNA and the protonated species of drugs with basic groups through the determination of the affinity constants, the ...
Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis
(Public Library of Science, 2015)
Pulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix destruction resulting in cavitation is not well ...
User-centered design improves the usability of drug-drug interaction alerts: Experimental comparison of interfaces
(Academic Press Inc Elsevier Science, 2017-02)
Clinical Decision Support Systems can alert health professionals about drug interactions when they prescribe medications. The Hospital Italiano de Buenos Aires in Argentina developed an electronic health record with drug-drug ...
Enzyme Induction and Drug Metabolism
(Springer Nature Switzerland AG, 2021)
Enzyme induction is one of the most important underlying mechanism of drug-drug interactions (DDIs). It can be defined as an increase in the biosynthesis of metabolizing enzymes after the exposure of the organism to ...
Interaction between areas of the central nervous system in the control of water intake and arterial pressure in rats
(1984-01-01)
1. Water intake induced by injection of 0.2 M-NaCl into the lateral preoptic area was increased by the injection of angiotensin II into the subfornical organ of rats. The injection of hypertonic saline solution into the ...
Interaction between areas of the central nervous system in the control of water intake and arterial pressure in rats
(1984-01-01)
1. Water intake induced by injection of 0.2 M-NaCl into the lateral preoptic area was increased by the injection of angiotensin II into the subfornical organ of rats. The injection of hypertonic saline solution into the ...
Nanotechnology-based drug delivery systems for treatment of hyperproliferative skin diseases - a review
(2013-04-12)
The chronic hyperproliferative diseases (CHD) include cancer, precancerous lesions and diseases of unknown etiology such as psoriasis. Various drugs have been used in the treatment of CHD, such as antiproliferative and ...