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CpG DNA as a Th1-promoting adjuvant in immunization against Trypanosoma cruzi
(Elsevier, 2000-09)
Th1-type immune response plays a critical role in resistance to Trypanosoma cruzi infection. We asked whether a synthetic oligodeoxynucleotide that contains immunostimulatory CpG motifs (CpG ODN), known to promote a Th1 ...
A DNA vaccine containing PPE68 induces humoral response in cattle
(2013)
In this study, we used an approach known to stimulate Th1 immune responses, DNA vaccination, to produce PPE68, a RD1 antigen absent in BCG. We found that after four intramuscular doses (1/every 2 weeks), the production of ...
A DNA vaccine containing PPE68 induces humoral response in cattle
(2013)
In this study, we used an approach known to stimulate Th1 immune responses, DNA vaccination, to produce PPE68, a RD1 antigen absent in BCG. We found that after four intramuscular doses (1/every 2 weeks), the production of ...
Role of TLR9 methylation on its active transcription in apical inflammation
(WILEY, 2022)
Aim To explore the methylation pattern, its role in transcriptional regulation and potential modifiers of methylation of the TLR9 gene in chronic periapical inflammation. Methodology In this cross-sectional study, apical ...
DNA damage induced by photoexcited bare and loaded Microporous Coordination Polymers
(Royal Society of Chemistry, 2015-05)
We report on interactions of cell free double-stranded DNA (dsDNA) with a selected subgroup of Microporous Coordination Polymers (MCPs). In particular, we have studied the influence of different metal ion constituents and ...
Identification of bovine CpG SNPs as potential targets for epigenetic regulation via DNA methylation
(2019-01-01)
Methylation patterns established and maintained at CpG sites may be altered by single nucleotide polymorphisms (SNPs) within these sites and may affect the regulation of nearby genes. Our aims were to: 1) identify and ...
Do screening ao mecanismo de ação, uma contribuição para a descoberta de ciclopaladados bioativos: a atividade leishmanicida de CP2 e seu efeito inibitório frente à DNA topoisomerase 1B de Leishmania
(Universidade Estadual Paulista (Unesp), 2017-03-10)
Leishmaniasis are diseases globally distributed in tropical and subtropical areas of the world and Leishmania spp. are the etiological agents of the diseases. Numerous problems associated with available treatments of the ...
Análise de metilação em diferentes regiões de genes supressores de tumor no carcinoma de células escamosas bucal
(Universidade Estadual Paulista (Unesp), 2020-05-04)
O carcinoma de células escamosas bucal (CCEB) apresenta alterações epigenéticas, como a metilação de DNA, na região promotora de genes supressores de tumor (GST), mas pouco se sabe em relação a outras regiões gênicas. Este ...
Comprehensive analysis of DNA methylation and prediction of response to neoadjuvanttherapy in locally advanced rectal cancer
(2020-11-01)
The treatment for locally advanced rectal carcinomas (LARC) is based on neoadjuvant chemoradiotherapy (nCRT) and surgery, which results in pathological complete response (pCR) in up to 30% of patients. Since epigenetic ...
Elastic properties of nanowires
(Amer Inst PhysicsMelvilleEUA, 2006)