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Charged residues at the first transmembrane region contribute to the voltage dependence of the slow gate of connexins
(2016)
Connexins (Cxs) are a family of membrane-spanning proteins that form gap junction channels and hemichannels. Connexin-based channels exhibit two distinct voltage-dependent gating mechanisms termed slow and fast gating. ...
Connexins and Pannexins in Bone and Skeletal Muscle
(2017)
Purpose of review To discuss current knowledge on the role of connexins and pannexins in the musculoskeletal system. Recent findings Connexins and pannexins are crucial for the development and maintenance of both bone and ...
Expression of Connexins in Normal and Neoplastic Canine Bone Tissue
(AMER COLL VET PATHOLOGIST, 2009)
Previous studies showed that intercellular communication by gap junctions has a role in bone formation. The main connexin involved in the development, differentiation, and regulation of bone tissue is connexin (Cx) 43. In ...
Co-expression and regulation of connexins 36 and 43 in cultured neonatal rat pancreatic islets
(Natl Research Council CanadaOttawaCanadá, 2005)
Regulation of Connexins Expression Levels by MicroRNAs, an Update
(Frontiers Research Foundation, 2016)
Control of cell-cell coordination and communication is regulated by several factors, including paracrine and autocrine release of biomolecules, and direct exchange of soluble factors between cells through gap junction ...
Functional hemichannels formed by human connexin 26 expressed in bacteria
(© 2015 The Author(s) CC-BY Licence, 2015)
Gap-junction channels (GJCs) communicate the cytoplasm of adjacent cells and are formed by head-to-head association of two hemichannels (HCs), one from each of the neighbouring cells. GJCs mediate electrical and chemical ...
Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness
(Springer, 2016)
Gap-junction channels (GJCs) are formed by head-to-head association of two hemichannels (HCs, connexin hexamers). HCs and GJCs are permeable to ions and hydrophilic molecules of up to Mr ~1 kDa. Hearing impairment of genetic ...
Extracellular Cysteine in Connexins: Role as Redox Sensors
(Lausanne : Frontiers Research Foundation, 2016)
Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa. Similarly, the opening ...