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First Century of Chagas' Disease: An Overview on Novel Approaches to Nifurtimox and Benznidazole Delivery Systems
(John Wiley & Sons Inc, 2012-03)
Hundred years after the discovery of Chagas' disease, there is a lack of effective treatment to control this neglected disease caused by the parasite Trypanosoma cruzi. The transmission is primarily through vector-borne ...
A Novel Prototype Device for Microencapsulation of Benznidazole: In Vitro/In Vivo Studies
(Springer, 2020-04)
This study was aimed to design a simple and novel prototype device for the production of polymeric microparticles. To prove the effectiveness of this device, benznidazole microparticles using chitosan as carrier and NaOH, ...
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole
(Public Library of Science, 2021)
Pentamidine antagonizes the benznidazole's effect in vitro, and lacks of synergy in vivo: Implications about the polyamine transport as an anti-Trypanosoma cruzi target
(Academic Press Inc., 2016)
© 2016 Elsevier Inc.Benznidazole is the first-line drug used in treating Chagas disease, which is caused by the parasite Trypanosoma cruzi (T. cruzi). However, benznidazole has limited efficacy and several adverse reactions. ...
Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo
(Public Library of Science, 2016)