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High Affinity Leptin Receptors Are Present in Human Mesenchymal Stem Cells (MSCs) Derived From Control and Osteoporotic Donors
(AMER SOC BONE & MINERAL RES., 2004-10)
There are disparate observations on central and peripheral effects of leptin, but several studies consistently
support its role as a link between fat and bone. Bone marrow stroma contains mesenchymal stem cells (MSCs), ...
OCT4 silencing triggers its epigenetic repression and impairs the osteogenic and adipogenic differentiation of mesenchymal stromal cells
(Molecular Diversity Preservation International, 2019-07)
Mechanisms mediating mesenchymal stromal/stem cells’ (MSCs) multipotency are unclear. Although the expression of the pluripotency factor OCT4 has been detected in MSCs, whether it has a functional role in adult stem cells ...
Increased adipogenesis of osteoporotic human-mesenchymal stem cells (MSCs) is characterized by impaired leptin action
(WILEY-LISS, DIV JOHN WILEY & SONS INC, 2008-03-01)
The bone marrow contains mesenchymal stem cells (MSCs) that differentiate to the osteogenic and adipogenic lineages. The fact that the decrease in bone volume of age-related osteoporosis is accompanied by an increase in ...
Downregulation of the protein synthesis machinery is a major regulatory event during early adipogenic differentiation of human adipose-derived stromal cells
(Elsevier Science, 2017-12)
Commitment of adult stem cells involves the activation of specific gene networks regulated from transcription to protein synthesis. Here, we used ribosome profiling to identify mRNAs regulated at the translational level, ...