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The emerging role of Wnt5a in the promotion of a pro-inflammatory and immunosuppressive tumor microenvironment
(Springer, 2020-05-20)
Wnt5a is the prototypical activator of the non-canonical Wnt pathways, and its overexpression has been implicated in the progression of several tumor types by promoting cell motility, invasion, EMT, and metastasis. Recent ...
Estudo da via de sinalização Wnt canônica e não canônica no carcinoma e na mucosa colorretal não neoplásica por imuno-histoquímica com tissue microarray (TMA)
(Universidade Federal de São Paulo (UNIFESP), 2012)
Objetivos: Detectar as proteinas integrantes da via de sinalizacao Wnt canonica e nao canonica e verificar sua integridade no carcinoma colorretal e no epitelio colorretal nao neoplasico. Metodo: Foram estudados 64 doentes ...
Wnt-5a/frizzled9 receptor signaling through the Gαo-Gβγ complex regulates dendritic spine formation
(American Society for Biochemistry and Molecular Biology, 2016-09)
Wnt ligands play crucial roles in the development and regulation of synapse structure and function. Specifically, Wnt-5a acts as a secreted growth factor that regulates dendritic spine formation in rodent hippocampal ...
El receptor Ror1 y su rol en cancerThe role of Ror1 receptor in cancerO receptor Ror1 e seu papel em câncer
(Federación Bioquímica de la Provincia Buenos Aires, 2011-12)
Las proteínas Wnt son ligandos que activan señales involucradas en proliferación, sobrevida, adhesión, migración, diferenciación y polaridad celular y como tal están involucradas en una amplia variedad de patologías. A ...
Estudo da via Wnt no endométrio normal e no câncer de endométrio, em mulheres após a menopausa
(Universidade Federal de São Paulo (UNIFESP), 2011-06-29)
The Wnt family is involved in tumorigenesis of several tissues as well in embriogenesis. In order to analize the canonical and noncanonical Wnt pathway in atrophic endometrium and endometrial adenocarcinoma, we evaluated ...
WNT Signaling Is a Key Player in Alzheimer’s Disease
(Springer Science and Business Media Deutschland GmbH, 2021)
The cellular processes regulated by WNT signaling have been mainly studied during embryonic development and cancer. In the last two decades, the role of WNT in the adult central nervous system has been the focus of interest ...
Non-Canonical WNT/Wnt5a Pathway Activity in Circulating Monocytes of Untreated Psoriatic Patients: An Exploratory Study of Its Association with Inflammatory Cytokines and Cardiovascular Risk Marker-ADAMTS7
(2023)
The leading cause of death in psoriasis is cardiovascular disease. The determinants that induce the increase in this risk are not known. The systemic inflammatory process is dependent on lymphocytes and monocytes, as has ...
Avaliação da diferenciação mieloide estimulada por IL-3 e GM-CSF: modulação por Wnt
(Universidade Federal de São Paulo (UNIFESP), 2020-03-26)
Hematopoiesis is the process in which blood cells are produced and that starts with multipotent and undifferentiated stem cells and ends with with the production of several highly specialized cells, such as red cells ...
Consequences of endogenous and exogenous WNT signaling for development of the preimplantation bovine embryo
(2017-01-01)
The specific role of WNT signaling during preimplantation development remains unclear. Here, we evaluated consequences of activation and inhibition of ß-catenin (CTNNB1)-dependent and -independent WNT signaling in the ...