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CYP3A5 and UGT1A9 polymorphisms influence immunosuppressive therapy in pediatric kidney transplant recipients
(Frontiers Media, 2021)
Background: Tacrolimus (TAC) and mycophenolic acid (MPA) are the main immunosuppressive drugs used in pediatric kidney transplantation. Single nucleotide polymorphisms (SNPs) in metabolizing enzymes and transporters might ...
Polimorfismo do Gene UGT1A1 associado à toxicidade em pacientes oncológicos tratados com irinotecano (CPT-11) em Belém/PA
(Universidade Federal do ParáBrasilNúcleo de Pesquisas em OncologiaUFPAPrograma de Pós-Graduação em Oncologia e Ciências Médicas, 2017)
Prevalencia de síndrome de Gilbert y sus determinantes genéticas en población chilena
(2013)
Background: In Europeans the TATA box TA7 repeat promoter variant in the UGT1A1 gene (UGT1A1*28) is the major determinant of bilirubin levels. Aim: To study the prevalence of Gilbert Syndrome (GS) and its genetic determinants ...
Análisis transcriptómico y proteómico de la biosíntesis de glucósidos esteviol y perfil metabolómico en Stevia rebaudiana
(Universidad Nacional de Tumbes, 2020)
Stevia rebaudiana es un arbusto herbáceo perenne, pertenece a la familia Asteraceae, nativo del sur de América endémica de Amambay – Paraguay. Su importancia en el mercado radica por presentar edulcorantes no calóricos 200 ...
Loci From a Genome-Wide Analysis of Bilirubin Levels Are Associated With Gallstone Risk and Composition
(W B SAUNDERS CO-ELSEVIER INC, 2010)
BACKGROUND & AIMS: Genome-wide association studies have mapped loci that are associated with serum levels of bilirubin. Bilirubin is a major component of gallstones so we investigated whether these variants predict gallstone ...
Avaliação de polimorfismos genéticos e a dose terapêutica da varfarina em pacientes com trombose: um estudo de coorte
(Universidade Federal de Minas GeraisUFMG, 2014-10-31)
The treatment of thromboembolic diseases aims to maintain a stable and personalized anticoagulation, for which the warfarin anticoagulant is the treatment of choice. The influence of several factors on the action of warfarin ...