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Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents
(Elsevier B. V., 2014-11-24)
In the search for new therapeutic tools against tuberculosis and to further address the therapeutic potential of pyridine-2-thiol 1-oxide (Hmpo) metal complexes, two new octahedral [M(III)(mpo)3] complexes, with M = Ga or ...
Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents
(2014-11-24)
In the search for new therapeutic tools against tuberculosis and to further address the therapeutic potential of pyridine-2-thiol 1-oxide (Hmpo) metal complexes, two new octahedral [M<sup>III</sup>(mpo)<inf>3</inf>] ...
Curcumin-cinnamaldehyde hybrids as antiproliferative agents against women’s cancer cells
(2021-01-01)
Curcumin and cinnamaldehyde are natural products whose antineoplastic activity has been well explored in biological evaluations. However, their poor chemical stability under physiological conditions has been an obstacle ...
Design of novel iron compounds as potential therapeutic agents against tuberculosis
(Elsevier Science Inc, 2010-11)
In the search for new therapeutic tools against Tuberculosis two novel iron complexes, [Fe(L-H)3], with 3-aminoquinoxaline-2-carbonitrile N1,N4-dioxide derivatives (L) as ligands, were synthesized, characterized by a ...
Therapeutic opportunities for PLK1 inhibitors: Spotlight on BRCA1-deficiency and triple negative breast cancers
(Elsevier Science, 2020-05)
Polo-Like Kinases (PLKs) are central players of mitotic progression in Eukaryotes. Given the intimate relationship between cell cycle progression and cancer development, PLKs in general and PLK1 in particular have been ...
Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models
(Future Medicine, 2020-03)
Aim: According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action.
Materials & methods: We describe in vitro studies ...
Fast two-photon neuronal imaging and control using a spatial light modulator and ruthenium compounds
(SPIE - the international society for optics and photonics, 2010-03)
We have developed a spatial light modulator (SLM) based microscope that uses diffraction to shape the incoming two-photon laser source to any arbitrary light pattern. This allows the simultaneous imaging or photostimulation ...
Reactive oxygen species-mediated degradation of antidiabetic compounds: Cytotoxic implications of their photodegradation products
(Wiley Blackwell Publishing, Inc, 2018-11)
Reactive oxygen species (ROS) have been described in their double physiological function, helping in the maintenance of health as well as contributing to oxidative stress. Diabetes mellitus is a chronical disease nearly ...