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Muscarinic Receptors as Targets for Metronomic Therapy in Breast Cancer.
(Bentham Science Publishers, 2016-01)
BACKGROUND: It is actually known that acetylcholine works as a signaling molecule in non-neuronal cells and tissues, in addition to its neuronal function as neurotransmitter. It can act on two types of receptors nicotinic ...
The long arm of BRAF V600E gets to mTORC1
(Wiley, 2009-03)
Despite the disappointing results of early clinical studies, targeting the BRAF ⁄ MEK⁄ extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAPK) pathway is still a subject of investigation due ...
Heat shock proteins are essential components in transformation and tumor progression: Cancer cell intrinsic pathways and beyond
(Institute for Digital Multidisciplinary Publication, 2019-09)
Heat shock protein (HSP) synthesis is switched on in a remarkably wide range of tumor cells, in both experimental animal systems and in human cancer, in which these proteins accumulate in high levels. In each case, elevated ...
Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways
(SPRINGER, 2010)
Glypican-3 (GPC3) is a proteoglycan involved in proliferation and cell survival. Several reports demonstrated that GPC3 is downregulated in some tumors, such as breast cancer. Previously, we determined that GPC3 reexpression ...
Teneurins: An Integrative Molecular, Functional, and Biomedical Overview of Their Role in Cancer.
(2018)
Teneurins are large transmembrane proteins originally identified in Drosophila. Their essential role in development of the central nervous system is conserved throughout species, and evidence supports their involvement in ...
Classical and non-classical thyroid hormone intracellular pathways involved in T lymphoma growth
(Bentham Science Publishers, 2015-04)
Thyroid hormones (THs) are important regulators of cell physiology. They are essential for the normal development and growth of mammals, especially for the neural differentiation and the regulation of the metabolism and ...
Defining the Molecular Basis of Tumor Metabolism: a Continuing Challenge Since Warburg's Discovery
(Karger, 2011-01-01)
Cancer cells are the product of genetic disorders that alter crucial intracellular signaling pathways associated with the regulation of cell survival, proliferation, differentiation and death mechanisms. the role of oncogene ...