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TRPC3 regulates islet beta-cell insulin secretion
(Wiley, 2023)
Deep Transcriptomic Profiling of M1 Macrophages Lacking Trpc3
(Nature Publishing Group, 2017-01)
In previous studies using mice with macrophage-specific loss of TRPC3 we found a significant, selective effect of TRPC3 on the biology of M1, or inflammatory macrophages. Whereas activation of some components of the unfolded ...
Reduced calcification and osteogenic features in advanced atherosclerotic plaques of mice with macrophage-specific loss of TRPC3
(Elsevier Ireland, 2018-03)
Background and aims: Recent in vitro studies have showed that in macrophages, deletion of the non-selective Ca2+-permeable channel TRPC3 impairs expression of the osteogenic protein BMP-2. The pathophysiological relevance ...
Vascular smooth muscle TRPC3 channels facilitate the inverse hemodynamic response during status epilepticus
(Nature, 2020-12)
Human status epilepticus (SE) is associated with a pathological reduction in cerebral blood flow termed the inverse hemodynamic response (IHR). Canonical transient receptor potential 3 (TRPC3) channels are integral to the ...
TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons
(eLife, 2021)
Abstract: Midbrain dopamine (DA) neurons are slow pacemakers that maintain extracellular DA
levels. During the interspike intervals, subthreshold slow depolarization underlies autonomous pacemaking
and determines its ...
Transient receptor potential canonical 3 (TRPC3) channels are required for hypothalamic glucose detection and energy homeostasis
(American Diabetes Association, 2017)
The mediobasal hypothalamus (MBH) contains neurons capable of directly detecting metabolic signals such as glucose to control energy homeostasis. Among them, glucose-excited (GE) neurons increase their electrical activity ...
Canonical transient receptor potential 6 channel deficiency promotes smooth muscle cells dedifferentiation and increased proliferation after arterial injury
(Elsevier, 2020-07)
Objective Previous studies showed the benefit of canonical transient receptor potential 6 (TRPC6) channel deficiency in promoting endothelial healing of arterial injuries in hypercholesterolemic animals. Long-term studies ...
Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced relaxations and nitric oxide production in mesenteric arteries: comparative study using wild-type and TRPC1−/- mice
(Landes Bioscience, 2019-01)
We have previously provided pharmacological evidence that stimulation of calcium-sensing receptors (CaSR) induces endothelium-dependent relaxations of rabbit mesenteric arteries through activation of heteromeric TRPV4/TRPC1 ...
Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced relaxations and nitric oxide production in mesenteric arteries: comparative study using wild-type and TRPC1-/- mice
(Taylor & Francis, 2019)
Abstract: We have previously provided pharmacological evidence that stimulation of calcium-sensing receptors (CaSR) induces endothelium-dependent relaxations of rabbit mesenteric arteries through activation of heteromeric ...
Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho
(Elsevier, 2017)
Abstract: Fibrosis is an exaggerated form of tissue repair that occurs with serious damage or repetitive injury and ultimately leads to organ failure due to the excessive scarring. Increased calcium ion entry through the ...