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Intact caveolae are required for proper extravillous trophoblast migration and differentiation
(Veterinary and Human Toxicology, 2019-09)
Caveolae constitute membrane domains critical for the organization and synchronization of different signaling molecules related to numerous cell processes such as cell migration, invasion, and differentiation. Caveolin-1 ...
A novel regulator of human villous trophoblast fusion: the Krüppel-like factor 6
(Oxford University Press, 2014-12)
Cell–cell fusion is an essential event during life. Throughout human pregnancy, the syncytiotrophoblast (STB) layer of the placenta is formed by continuous fusion of the underlying villous cytotrophoblasts, thus maintaining ...
Mitochondrial metabolism in human fresh villous trophoblast
(Elsevier Ireland, 2019)
Objectives: To study different metabolic parameters of the mitochondrialpopulation present in the villous trophoblast in the human termplacenta.Methods: This study was approved by the ethics committee of HospitalNacional ...
Trophoblast glycogen cells differentiate early in the mouse ectoplacental cone: putative role during placentation
(Springer, 2010-07-01)
The role of differentiated trophoblast glycogen cells (GCs) in the ectoplacental cone (EPC) has not been elucidated yet. Recently, GC progenitors have been shown to be present from embryonic day 7.5 (E7.5), but glycogen ...
Low oxygen tension induces Krüppel-Like Factor 6 expression in trophoblast cells
(W B Saunders Co Ltd, 2016-09)
The transcription factor Krüppel-Like Factor 6 (KLF6) has important roles in cell differentiation, angiogenesis, apoptosis, and proliferation. Furthermore, there is evidence that KLF6 is required for proper placental ...
A local innate immune response against Trypanosoma cruzi in the human placenta: The epithelial turnover of the trophoblast
(Academic Press, 2016)
Congenital Chagas disease, caused by Trypanosoma cruzi, is partially responsible for the progressive globalization of Chagas disease despite of its low transmission rate. The probability of congenital transmission depends ...
Modulation and recruitment of inducible regulatory T cells by first trimester trophoblast cells
(Wiley Blackwell Publishing, Inc, 2012-01)
Problem The specialized regulatory T-cells (Treg) population, essential for maternal tolerance of the fetus, performs its suppressive actions in the critical peri-implantation phase of pregnancy. In the present work, we ...
Growth and development of the placenta in the capybara (Hydrochaeris hydrochaeris)
(LONDON, 2009)
The guinea pig is an attractive model for human pregnancy and placentation, mainly because of its haemomonochorial placental type, but is rather small in size. Therefore, to better understand the impact of body mass, we ...
New insights into the role of placental aquaporins and the pathogenesis of preeclampsia
(Frontiers Media S.A., 2019)
Accumulated evidence suggests that an abnormal placentation and an alteredexpression of a variety of trophoblast transporters are associated to preeclampsia. In this regard, an abnormal expression of AQP3 and AQP9 was ...
Impact of chlorpyrifos on human villous trophoblasts and chorionic villi
(Academic Press Inc Elsevier Science, 2017-08-15)
Placental barrier regulates maternal-fetal interchange protecting the baby from damage caused by substances found in the uterine environment or circulating in the vascular system. Organophosphate (OP) pesticides are a ...