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A physiological role for inducible FOXP3+ TREG cells: Lessons from women with reproductive failure
(Elsevier Inc, 2010-09)
We have previously shown a decreased frequency and function of Tregs in women suffering from recurrent spontaneous abortions (RSA). In the current study, we first investigated the expression of FOXP3 after T-cell activation. ...
Quantification of Treg cells in peripheral blood and lymph nodes of dogs with multicentric lymphoma
(2017-11-01)
Lymphoma is a malignant tumor characterized by cell proliferation of lymphoid origin and corresponds to 90% of all hematopoietic neoplasms of dogs. Regulatory T cells (Tregs) have been the target of many investigations in ...
Imbalanced expression of functional surface molecules in regulatory and effector T cells in systemic lupus erythematosus
(Associação Brasileira de Divulgação Científica, 2014-08-01)
Regulatory T (TREG) cells play an important role in maintaining immune tolerance and avoiding autoimmunity. We analyzed the expression of membrane molecules in TREG and effector T cells in systemic lupus erythematosus ...
Senescent CD4+CD28− T lymphocytes as a potential driver of Th17/Treg imbalance and alveolar bone resorption during periodontitis
(MDPI, 2022)
Senescent cells express a senescence-associated secretory phenotype (SASP) with a pro-inflammatory bias, which contributes to the chronicity of inflammation. During chronic inflammatory diseases, infiltrating CD4(+) T ...
Linfocitos T reguladores inducibles producen factores generadores de linfocitos T reguladores in Vitro
(Universidad de Chile, 2011)
Hace un siglo Paul Ehrlich propuso que el sistema inmune estaba programado
para evitar la generacion de respuestas autoinmunes en lo que denomino "horror
autotoxicus" (Himmelweit,1956-1960). En la actualidad los avances ...
Análise do padrão de resposta Th17 e de células T regulatórias em pacientes com a forma digestiva da doença de Chagas crônica
(Universidade Estadual Paulista (Unesp), 2016-03-01)
A Doença de Chagas (DC), cujo agente etiológico é o protozoário Trypanosoma cruzi (T. cruzi), tornou-se nos últimos anos um grave problema de saúde pública, mesmo em países não-endêmicos. Um importante desafio para os ...
Neuropilin-1 in transplantation tolerance
(2013)
In the immune system, Neuropilin-1 (Nrp1) is a molecule that plays an important role in establishing the immunological synapse between dendritic cells (DCs) and T cells. Recently, Nrp1 has been identified as a marker that ...
Combination Chemotherapy with Firocoxib Induces Reduction of Regulatory T Cells in Dogs with Multicentric B Cell Lymphoma
(Univ Agriculture, Fac Veterinary Science, 2019-01-01)
The aim of this study was to quantify T cells (CD4+, CD8+ and Treg), in dogs with multicentric lymphoma treated with a conventional CHOP protocol or with one in which firocoxib was used instead of prednisone. Twenty-one ...
Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation
(Hindawi Publishing, 2015)
Maintaining the identity of Foxp3+ regulatory T cells (Tregs) is critical for controlling immune responses in the gut, where an
imbalance between Tregs and T effector cells has been linked to inflammatory bowel disease. ...