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The roles of HicBA and a novel toxin-antitoxin-like system, TsxAB, in the stability of IncX4 resistance plasmids in Escherichia coli
(Oxford University Press, 2019)
Objectives: To identify toxin-antitoxin (TA)-like plasmid stability loci on IncX4 plasmids. Methods: TA-like loci were identified bioinformatically and their contribution to stability of the IncX4 plasmid pJIE143 was tested ...
Variabilidad en secuencias proteicas de los sistemas Toxina-Antitoxina en Mycobacterium tuberculosis
(2017)
El agente causal de la tuberculosis es Mycobacterium tuberculosis, un patógeno dividido en 7 linajes asociados a zonas geográficas específicas y con diferencias en su comportamiento. Una característica notable en M. ...
Design and synthesis of peptides from bacterial ParE toxin as inhibitors of topoisomerases
(Elsevier France-editions Scientifiques Medicales Elsevier, 2012-08-01)
Toxin-antitoxin (TA) proteic systems encode a toxin and an antitoxin that regulate the growth and death of bacterial cells under various stress conditions. The ParE protein is a toxin that inhibits DNA gyrase activity and ...
Design and synthesis of peptides from bacterial ParE toxin as inhibitors of topoisomerases
(Elsevier France-editions Scientifiques Medicales Elsevier, 2012-08-01)
Toxin-antitoxin (TA) proteic systems encode a toxin and an antitoxin that regulate the growth and death of bacterial cells under various stress conditions. The ParE protein is a toxin that inhibits DNA gyrase activity and ...
Síntese, caracterização e estudos de interação de um análogo da antitoxina CcdA empregando fluorescência no estado estacionário
(Sociedade Brasileira de Química, 2010-01-01)
Toxin-antitoxin (TA) systems contribute to plasmid stability by a mechanism called post-segregational killing. The ccd was the first TA system to be discovered with CcdB being the toxin and CcdA the antitoxin. CcdA, an 8.3 ...
Síntese, caracterização e estudos de interação de um análogo da antitoxina CcdA empregando fluorescência no estado estacionário
(Sociedade Brasileira de Química, 2010-01-01)
Toxin-antitoxin (TA) systems contribute to plasmid stability by a mechanism called post-segregational killing. The ccd was the first TA system to be discovered with CcdB being the toxin and CcdA the antitoxin. CcdA, an 8.3 ...
Desenvolvimento e caracterização de lipossomas de ramnolipídeos encapsulados com peptídeos inibidores de topoisomerases bacterianas
(Universidade Estadual Paulista (Unesp), 2018-03-15)
O sistema ParE-ParD é um sistema toxina-antitoxina (TA) onde ParE atua como a toxina e ParD a antitoxina. ParE tem comprovada atividade de inibição do sítio catalítico das enzimas DNA girase e Topoisomerase IV (Topo IV), ...
Rhamnolipid-based liposomes as promising nano-carriers for enhancing the antibacterial activity of peptides derived from bacterial toxin-antitoxin systems
(2021-01-01)
Background: Antimicrobial resistance poses substantial risks to human health. Thus, there is an urgent need for novel antimicrobial agents, including alternative compounds, such as peptides derived from bacterial toxin-antitoxin ...
Peptídeos sintéticos no estudo do sistema toxina-antitoxina ParE/ParD
(Universidade Estadual Paulista (Unesp), 2017-06-27)
O sistema ParE-ParD é um sistema Toxina-Antitoxina (TA) do tipo II (composto por duas proteínas) encontrado no plasmídeo RK2 de uma gama de bactérias. A antitoxina ParD (9kDa) é capaz de neutralizar a citotoxicidade da ...
A new member of the ribbon-helix-helix transcription factor superfamily from the plant pathogen Xanthomonas axonopodis pv. citri
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010)
XACb0070 is an uncharacterized protein coded by the two large plasmids isolated from Xanthomonas axonopodis pv. cirri, the agent of citrus canker and responsible for important economical losses in citrus world production. ...