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The metabolic and toxicological considerations for immunosuppressive drugs used during pancreas transplantation
(Informa Healthcare, 2012-12-01)
Introduction: Pancreas-kidney transplant is an effective treatment for patients with insulin-dependent dabetes and chronic renal failure. Reduction in technical failure loss and early acute rejection rates contributed to ...
The Epididymis as a Target for Toxicants
(2017-12-15)
The epididymis is the organ in which sperm mature by developing the capacity for progressive motion and fertilizing ability. There is evidence that sperm quality in humans and other animals has diminished, in parallel with ...
International recommendations for training future toxicologic pathologists participating in regulatory-type, nonclinical toxicity studies
(Elsevier Gmbh, Urban & Fischer Verlag, 2014)
Sustainability, natural and organic cosmetics: Consumer, products, efficacy, toxicological and regulatory considerations
(2015-01-01)
The interest in sustainable products has increased along the years, since the choice of products, packaging and production processes have a great impact on the environment. These products are classified by regulatory ...
Mechanisms of lindane-induced hepatotoxicity: Alterations of respiratory activity and sinusoidal glutathione efflux in the isolated perfused rat liver
(Informa Healthcare, 1991)
1. Lindane (25-60 mg/kg) at 24 h after dosage induced a dose-dependent increase in oxygen consumption by perfused rat livers, an effect not observed at early times (2-6 h) after administration. About 60% of the increase ...
The effect of calcium on disodium monofluorophosphate absorption from the gastrointestinal tract of rats
(1992)
The absorption of fluoride from disodium monofluorophosphate with or without added calcium has been studied in ligated stomachs and duodena of rats, in vivo. Measurements of fluoride absorption from sodium fluoride were ...