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Quantification of Treg cells in peripheral blood and lymph nodes of dogs with multicentric lymphoma
(2017-11-01)
Lymphoma is a malignant tumor characterized by cell proliferation of lymphoid origin and corresponds to 90% of all hematopoietic neoplasms of dogs. Regulatory T cells (Tregs) have been the target of many investigations in ...
Combination Chemotherapy with Firocoxib Induces Reduction of Regulatory T Cells in Dogs with Multicentric B Cell Lymphoma
(Univ Agriculture, Fac Veterinary Science, 2019-01-01)
The aim of this study was to quantify T cells (CD4+, CD8+ and Treg), in dogs with multicentric lymphoma treated with a conventional CHOP protocol or with one in which firocoxib was used instead of prednisone. Twenty-one ...
T Regulatory cells from non-obese diabetic mice show low responsiveness to IL-2 stimulation and exhibit differential expression of anergy-related and ubiquitination factors
(Frontiers Media S.A., 2019-11)
Foxp3+ Regulatory T cells (Tregs) are pivotal for the maintenance of tolerance. Alterations in their number and/or function have been proposed to occur in the autoimmune-prone non-obese diabetic (NOD) mouse. Comparing the ...
Interleukin (IL)-35 is raising our expectations
(Sociedad Médica de Santiago, 2010)
Avaliação fenotípica das células T reguladoras CD4+CD25+CD127LOW em pacientes com lúpus eritematoso sistêmico
(Universidade Federal de São Paulo (UNIFESP), 2009-04-29)
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that is part of the group of rheumatic autoimmune inflammatory diseases, being characterized by heterogeneous clinical and laboratory manifestations. The ...
The role of interleukin-6 signalling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthritis
(Wiley, 2017)
Therapeutic blockage of cytokine signalling in autoimmune diseases has improved our understanding of the role of these cytokines in triggering, shaping and perpetuating autoimmune responses. In rheumatoid arthritis (RA), ...
Participação de citocinas relacionadas às respostas Th17/Treg na inflamação periapical inflamatória crônica
(Universidade Federal de Minas GeraisUFMG, 2017-07-21)
Inflammatory periapical disease is a sequel of the infection and pulp necrosis. It represents the host defense response to aggression from the root canal. Chronic periapical lesions are developed in response to the maintenance ...
Senescent CD4+CD28− T lymphocytes as a potential driver of Th17/Treg imbalance and alveolar bone resorption during periodontitis
(MDPI, 2022)
Senescent cells express a senescence-associated secretory phenotype (SASP) with a pro-inflammatory bias, which contributes to the chronicity of inflammation. During chronic inflammatory diseases, infiltrating CD4(+) T ...
Neuropilin-1 in transplantation tolerance
(2013)
In the immune system, Neuropilin-1 (Nrp1) is a molecule that plays an important role in establishing the immunological synapse between dendritic cells (DCs) and T cells. Recently, Nrp1 has been identified as a marker that ...