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Delivery of gold nanoparticles to the brain by conjugation with a peptide that recognizes the transferrin receptor
(2012)
The treatment of Alzheimer's disease and many other brain-related disorders is limited because of the presence of the blood-brain barrier, which highly regulate the crossing of drugs. Metal nanoparticles have unique features ...
Inhibitory effect of a toxic peptide isolated from a waterbloom of Microcystis sp. (cyanobacteria) on iron uptake by rabbit reticulocytes
(1990)
M. Rojas, M. T. Nuñez and F. Zambrano. Inhibitory effect of a toxic peptide isolated from a waterbloom of Microcystis sp. (cyanobacteria) on iron uptake by rabbit reticulocytes. Toxicon 28, 1325-1332, 1990.-The effect of ...
Optimizing Circulating Tumor Cells’ Capture Efficiency of Magnetic Nanogels by Transferrin Decoration
(MDPI AG, 2018-02-11)
Magnetic nanogels (MNGs) are designed to have all the required features for their use as highly efficient trapping materials in the challenging task of selectively capturing circulating tumor cells (CTCs) from the bloodstream. ...
Mobilization of iron from endocytic vesicles. The effects of acidification and reduction
(1990)
The factors necessary to dissociate iron from transferrin in endocytic vesicles and to mobilize the iron across the vesicle membrane were studied in a preparation of endocytic vesicles markedly enriched in transferrin-transferrin ...
Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells
(Taylor & Francis Ltd, 2011-11)
A number of antibodies have been developed that induce lethal iron deprivation (LID) by targeting the transferrin receptor 1 (TfR1/CD71) and either neutralizing transferrin (Tf) binding, blocking internalization of the ...
Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1
(Pergamon-elsevier Science Ltd, 2012-10-17)
We previously developed an antibody-avidin fusion protein (ch128.1Av) that targets the human transferrin receptor 1 (TfR1) and exhibits direct cytotoxicity against malignant B cells in an iron-dependent manner. ch128.1Av ...
Antibody-based inhibition of pathogenic new world hemorrhagic fever mammarenaviruses by steric occlusion of the human transferrin receptor 1 apical domain
(American Society for Microbiology, 2021-09)
Pathogenic clade B New World mammarenaviruses (NWM) can cause Argentine, Venezuelan, Brazilian, and Bolivian hemorrhagic fevers. Sequence variability among NWM glycoproteins (GP) poses a challenge to the development of ...