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Association between immunohistochemical expression of topoisomerase II alpha, HER2 and hormone receptors and response to primary chemotherapy in breast cancer
(Pensiero Scientifico EditorRomeItália, 2006)
Síntese e caracterização de Complexos de Pd(II) com potencial atividade citotóxica e inibidores das enzimas Topoisomerase II
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2018-05-29)
It is known that cancer is a set of more than 100 diseases which are the second largest cause of death in the world. There are several factors related to the growth of tumors, showing different pathway for the planning of ...
Design and synthesis of peptides from bacterial ParE toxin as inhibitors of topoisomerases
(Elsevier France-editions Scientifiques Medicales Elsevier, 2014)
Determination of in vitro absorption in Caco-2 monolayers of anticancer Ru(II)-based complexes acting as dual human topoisomerase and PARP inhibitors
(Springer, 2019-02-01)
Due to their unique and versatile biochemical properties, ruthenium-based compounds have emerged as promising anticancer agents. Previous studies showed that three ruthenium(II) compounds: [Ru(pySH)(bipy)(dppb)]PF6 (1), ...
Peptídeos derivados da toxina ParE: síntese, estrutura e estudos de inibição de DNA topoisomerases
(Universidade Estadual Paulista (Unesp), 2014-01-29)
The toxin-antitoxin system ParE-ParD is a bacterial system of post-segregational death encoded in a wide range of hosts. ParE is a small protein of approximately 12 kDa encoded by parE gene. ParD is an antitoxin about 9 ...
Ruthenium(II)-mercapto Complexes with Anticancer Activity Interact with Topoisomerase IB
(2020-03-01)
Herein we present four new ruthenium(II) complexes: [Ru(mtz)2(dppb)] (1), [Ru(mmi)2(dppb)] (2), [Ru(dmp)2(dppb)] (3), and [Ru(mpca)2(dppb)] (4), where mtz = 2-mercaptothiazoline; mmi = 2-mercapto-1-methyl-imidazole; dmp = ...
Human topoisomerase inhibition and DNA/BSA binding of Ru(II)-SCAR complexes as potential anticancer candidates for oral application
(Springer, 2017-06-01)
Three ruthenium(II) phosphine/diimine/picolinate complexes were selected aimed at investigating anticancer activity against several cancer cell lines and the capacity of inhibiting the supercoiled DNA relaxation mediated ...
Inactivation of Trypanosoma cruzi and Crithidia fasciculata topoisomerase I by Fenton systems
(Maney Publishing, 2003-04)
Fenton systems (H2O2/Fe(II) or H2O2/Cu(II)) inhibited Trypanosoma cruzi and Crithidia fasciculata topoisomerase I activity. About 61-71% inactivation was produced by 25 μM Fe(II) or Cu(II) with 3.0 mM H2O2. Thiol compounds ...
Alterations of spermatogenesis in etoposide-treated rats: A stereological study
(Interciencia, 2002-05-01)
The etoposide is an anticancer drug that interacts with topoisomerase II. Thirty-day-old rats received intraperitonially 2mg/kg of etoposide for 30 consecutive days. Their testes were analyzed in the adult phase under light ...
Alterations of spermatogenesis in etoposide-treated rats: A stereological study
(Interciencia, 2002-05-01)
The etoposide is an anticancer drug that interacts with topoisomerase II. Thirty-day-old rats received intraperitonially 2mg/kg of etoposide for 30 consecutive days. Their testes were analyzed in the adult phase under light ...