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Mostrando ítems 21-30 de 134
Avaliação da atividade da telomerase em células-tronco de pacientes com displasia cortical de Taylor
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2015)
The Cortical dysplasia is one of the most frequent forms of malformations of cortical development, with a condition that causes a large portion of refractory partial epilepsy to drug treatment. This condition is characterized ...
Avaliação da atividade da telomerase em células-tronco de pacientes com displasia cortical de Taylor
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2015)
The Cortical dysplasia is one of the most frequent forms of malformations of cortical development, with a condition that causes a large portion of refractory partial epilepsy to drug treatment. This condition is characterized ...
Possible Involvement of Hsp90 in the Regulation of Telomere Length and Telomerase Activity During the Leishmania amazonensis Developmental Cycle and Population Proliferation
(2021-10-28)
The Leishmania developmental cycle comprises three main life forms in two hosts, indicating that the parasite is continually challenged due to drastic environmental changes. The disruption of this cycle is critical for ...
Hsp90-binding immunophilin FKBP51 forms complexes with hTERT enhancing telomerase activity
(Elsevier, 2016-05-17)
FK506-binding proteins are members of the immunophilin family of proteins. Those immunophilins associated to the 90-kDa-heat-shock protein, Hsp90, have been proposed as potential modulators of signalling cascade factors ...
Telomerase inhibition by a new synthetic derivative of the aporphine alkaloid boldine
(MDPI, 2018-04)
Telomerase, the enzyme responsible for cell immortality, is an important target in anti-cancer drug discovery. Boldine, an abundant aporphine alkaloid of Peumus boldus, is known to inhibit telomerase at non-toxic concentrations. ...
Telomere Length and Telomerase Activity in Foetal Membranes from Term and Spontaneous Preterm Births
(2020-01-01)
The reduction of telomere length, the protective cap structures of chromosomes, is one of the biomarkers of senescence (a mechanism of ageing), and ageing of foetal gestational tissues is associated with both term and ...
Homology model and docking-based virtual screening for ligands of human dyskerin as new inhibitors of telomerase for cancer treatment
(Molecular Diversity Preservation International, 2018-10)
Immortality is one of the main features of cancer cells. Tumor cells have an unlimited replicative potential, principally due to the holoenzyme telomerase. Telomerase is composed mainly by dyskerin (DKC1), a catalytic ...
Analysis of telomeric repeats and telomerase activity in human colon carcinoma cells with gene amplification
(Elsevier Science Inc, 2000-07)
COLO320DM and COLO320HSR are cell lines derived from a human malignant neuroendocrine colon carcinoma. Both lines have a 30–40-fold amplification of a large DNA domain containing the MYC oncogene. By using fluorescence in ...