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Reactive oxygen species released from astrocytes treated with amyloid beta oligomers elicit neuronal calcium signals that decrease phospho-Ser727-STAT3 nuclear content
(2018)
The transcription factor STAT3 has a crucial role in the development and maintenance of the nervous system. In this work, we treated astrocytes with oligomers of the amyloid beta peptide (A beta Os), which display potent ...
STAT3 neuronal como mediador de la toxicidad de los astrocitos estimulados con oligómeros del péptido β-amiloide
(2018)
El estrés oxidativo y la desregulación de la señalización de calcio son señales importantes en una variedad de enfermedades neurodegenerativas, incluyendo la enfermedad de Alzheimer (EA). El factor de transcripción STAT3 ...
Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease
(2012-01-01)
Recently, new treatment approaches have been developed to target the host component of periodontal disease. This review aims at providing updated information on host-modulating therapies, focusing on treatment strategies ...
Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease
(Universidade de São Paulo (USP), Faculdade de Odontologia de Bauru, 2012-03-01)
Recently, new treatment approaches have been developed to target the host component of periodontal disease. This review aims at providing updated information on host-modulating therapies, focusing on treatment strategies ...
Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease
(Universidade de São Paulo (USP), Faculdade de Odontologia de Bauru, 2012-03-01)
Recently, new treatment approaches have been developed to target the host component of periodontal disease. This review aims at providing updated information on host-modulating therapies, focusing on treatment strategies ...
STAT1, STAT3 and p38MAPK are involved in the apoptotic effect induced by a chimeric cyclic interferon-α2b peptide
(Elsevier Inc, 2010-02)
In the search of mimetic peptides of the interferon-α2b molecule (IFN-α2b), we have previously designed and synthesized a chimeric cyclic peptide of the IFN-α2b that inhibits WISH cell proliferation by inducing an apoptotic ...
Participación de STAT3 en la fibrosis de células endoteliales vasculares
(Universidad Andrés Bello, 2016)
Un evento importante para el desarrollo de enfermedades cardiovasculares corresponde a la disfunción endotelial. Entre otras características, este evento comprende la transformación fibrótica del endotelio mediante un ...
Regulation of cardiac JAK-2 in animal models of insulin resistance
(Taylor & Francis IncPhiladelphiaEUA, 2000)
Estudo da participação de reguladores negativos endógenos da atividade de STAT1 e STAT3 (SOCS1 e SOCS3) na doença periodontal experimental
(Universidade Estadual Paulista (Unesp), 2010-03-30)
A expressão de citocinas inflamatórias é um processo estritamente regulado por mecanismos variados, incluindo o controle da sinalização intracelular e da atividade transcricional por inibidores endógenos, os quais são pouco ...