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Beyond non-integer Hill coefficients: A novel approach to analyzing binding data, applied to Na + -driven transporters
(Rockefeller University Press, 2015-05)
Prokaryotic and eukaryotic Na(+)-driven transporters couple the movement of one or more Na(+) ions down their electrochemical gradient to the active transport of a variety of solutes. When more than one Na(+) is involved, ...
A Novel SLC5A5 variant reveals the crucial role of Kinesin Light Chain 2 in Thyroid Hormonogenesis
(Endocrine Society, 2021-07)
Context: Iodide transport defect (ITD) (Online Mendelian Inheritance in Man No. 274400) is an uncommon cause of dyshormonogenic congenital hypothyroidism due to loss-of-function variants in the SLC5A5 gene, which encodes ...
The KCNQ1-KCNE2 K+ channel is required for adequate thyroid I- uptake
(Federation of American Societies for Experimental Biology, 2012-08)
The KCNQ1 α subunit and the KCNE2 βsubunit form a potassium channel in thyroid epithelial cells. Genetic disruption of KCNQ1-KCNE2 causes hypothyroidism in mice, resulting in cardiac hypertrophy, dwarfism, alopecia, and ...
Association of low sodium-iodide symporter messenger ribonucleic acid expression in malignant thyroid nodules with increased intracellular protein staining
(ENDOCRINE SOC, 2008)
Context: The expression of sodium iodide symporter (NIS) is required for iodide uptake in thyroid cells. Benign and malignant thyroid tumors have low iodide uptake. However, previous studies by RT-PCR or immunohistochemistry ...
Emerging Therapeutics for Radioiodide-Refractory Thyroid Cancer
(Lifescience Global, 2016-05)
Although uncommon, thyroid cancer constitutes the main endocrine neoplasia with an incidence rate that has been increasing steadily over the past decades. Recently, remarkable advances have occurred in understanding the ...
Cutaneous Metastasis From a Classic Papillary Thyroid Cancer With Positive Immunohistochemical Staining for Sodium Iodide Symporter but No Response to Radioiodine Therapy
(Lippincott Williams & WilkinsPhiladelphiaEUA, 2009)
Low expression of sodium iodide symporter identifies aggressive thyroid tumors
(Elsevier B.V., 2003-10-08)
A decreased radioiodine uptake is frequently detected in differentiated thyroid carcinomas (DTC) and is associated with high recurrence rate and reduced survival. We investigated the correlation between NIS mRNA expression ...