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Estudo do efeito in vitro do parthenolide sobre a modulação das vias de ativação dos receptores TLR e NLR induzida por SOD1G93A
(Universidade Federal de São Paulo (UNIFESP), 2021)
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects motor neurons. The disease progresses gradually, leading to muscle atrophy, paralysis and even death from respiratory failure. Among the causes ...
Increased SOD1 association with chromatin, DNA damage, p53 activation, and apoptosis in a cellular model of SOD1-linked ALS
(ELSEVIER SCIENCE BV, 2010)
Mutations in the gene encoding cytosolic Cu,Zn-superoxide dismutase (SOD1) have been linked to familial amyotrophic lateral sclerosis (FALS). However the molecular mechanisms of motor neuron death are multifactorial and ...
Desbalanço superóxido-peróxido de hidrogênio versus seleno-L-metionina e castanha-do-Brasil: regulação diferencial in vitro de (seleno)enzimas
(Universidade Federal de Santa MariaBrasilBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaCentro de Ciências Naturais e Exatas, 2017-08-01)
Introduction: The coupled enzymatic reactions between the manganese-dependent superoxide dismutase (MnSOD/SOD2) and selenoenzyme glutathione peroxidase-1 (GPx-1) selenoenzyme are essential for mitochondrial redox balance ...
Peroxymonocarbonate and Carbonate Radical Displace the Hydroxyl-like Oxidant in the Sod1 Peroxidase Activity under Physiological Conditions
(AMER CHEMICAL SOC, 2009)
Despite being one of the most important antioxidant defenses, Cu,Zn-superoxide dismutase (Sod1) has been frequently associated with harmful effects, including neurotoxicity. This toxicity has been attributed to immature ...
Influência do polimorfismo Ala16Val do gene da enzima superóxido dismutase (SOD2) no efeito antioxidante in vitro do citrato de clomifeno
(Universidade Federal de Santa MariaBRFarmacologiaUFSMPrograma de Pós-Graduação em Farmacologia, 2011-08-16)
To investigate the in vitro antioxidant properties of the ovulation induction drug,
Citrate clomiphene (CC), and to access whether its effects are influenced by the
Ala16Val polymorphism in the SOD2 gene, which encodes ...