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The role of small GTPases in neuronal morphogenesis and polarity
(2012)
The highly dynamic remodeling and cross talk of the microtubule and actin cytoskeleton support neuronal morphogenesis. Small RhoGTPases family members have emerged as crucial regulators of cytoskeletal dynamics. In this ...
The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility
(Rockefeller Univ Press, 2013-09-23)
Vaccinia virus dissemination relies on the N-WASP– ARP2/3 pathway, which mediates actin tail formation underneath cell-associated extracellular viruses (CEVs). Here, we uncover a previously unappreciated role for the formin ...
Differential requirement of Rab22a for the recruitment of ER-derived proteins to phagosomes and endosomes in dendritic cells
(Taylor & Francis, 2017-11)
The recruitment of endoplasmic reticulum (ER) components to dendritic cell (DC) phagosomes and endosomes is a crucial event to achieve efficient cross-presentation of exogenous antigens. We have previously identified the ...
Both knock-down and overexpression of Rap2a small GTPase in macrophages result in impairment of NF-κB activity and inflammatory gene expression
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASUFMG, 2019)
Pequenas Ras GTPases são moléculas-chave que regulam uma variedade de respostas celulares em diferentes tipos de células. Rap1 desempenha funções importantes na regulação da biologia dos macrófagos durante a inflamação ...
Role of Rab27 in synaptic transmission at the squid giant synapse
(NATL ACAD SCIENCES, 2008)
Small GTPase Rab is a member of a large family of Ras-related proteins, highly conserved in eukaryotic cells, and thought to regulate specific type(s) and/or specific step(s) in intracellular membrane trafficking. Given ...
Rab22a controls MHC-I intracellular trafficking and antigen cross-presentation by dendritic cells
(Nature Publishing Group, 2016-12)
Cross-presentation by MHC class I molecules allows the detection of exogenous antigens by CD8+ T lymphocytes. This process is crucial to initiate cytotoxic immune responses against many pathogens (i.e. Toxoplasma gondii) ...