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Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep
(Nature Publishing Group, 2019-03-04)
The modern understanding of sleep is based on the classification of sleep into stages defined by their electroencephalography (EEG) signatures, but the underlying brain dynamics remain unclear. Here we aimed to move ...
The development of novel polypharmacological agents targeting the multiple binding sites of nicotinic acetylcholine receptors
(2016)
Introduction: Polypharmacology, which refers to the ability of a molecule to simultaneously interact with multiple target proteins, is shifting the drug discovery process from a 'one-drug-one-target' paradigm to a conceptual ...
Multiple binding sites in the nicotinic acetylcholine receptors: an opportunity for polypharmacolgy
(2015)
For decades, the development of selective compounds has been the main goal for chemists and biologists involved in drug discovery. However, diverse lines of evidence indicate that polypharmacological agents, i.e. those ...
Web discovery services: overview in the libraries of Brazilian public higher education institutionsServiços de descoberta: panorama nas bibliotecas das instituições públicas de ensino superior brasileiras
(Universidade Federal do Rio Grande do Sul, Faculdade de Biblioteconomia e Comunicação, Programa de Pós-Graduação em Ciência da Informação (Porto Alegre/RS), 2019)
Discovery of possible gene relationships through the application of self-organizing maps to DNA microarray databases
(2014)
DNA microarrays and cell cycle synchronization experiments have made possible the study of the mechanisms of cell cycle regulation of Saccharomyces cerevisiae by simultaneously monitoring the expression levels of thousands ...
A flow cytometer-based method to simultaneously assess activity and selectivity of compounds against the intracellular forms of Trypanosoma cruzi
(Elsevier Science, 2015-12-10)
Chagas disease is a major unsolved health issue in Latin America and an emerging threat worldwide. New drugs are urgently needed for chemotherapy as those available (benznidazole and nifurtimox) have variable efficacy and ...
Automatic Discovery of Complementary Learning Resources
Students in a learning experience can be seen as a community working simultaneously (and in some cases collaboratively) in a set of activities. During these working sessions, students carry out numerous actions that affect ...