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Rosuvastatin increases myocardial microvessels in SHR rats. Role of thioredoxin-1 and peroxiredoxin-2 expression
(Elsevier Ireland, 2014-03)
Beyond their lipid-lowering action, rosuvastatin possesses pleiotropic effects including anti-inflammatory, pro-angiogenic, antioxidant effects and protective actions against endothelial dysfunction [1,2]. The spontaneously ...
Ascorbic acid co-administered with rosuvastatin reduces reproductive impairment in the male offspring from male rats exposed to the statin at pre-puberty
(2018-08-01)
Obesity during childhood and adolescence is closely related to dysfunctions on lipid profile in children. Rosuvastatin is a statin that decreases serum total cholesterol. Ascorbic acid is an important antioxidant compound ...
A pharmacogenomic dissection of a Rosuvastatin-induced rhabdomyolysis case evokes the polygenic nature of adverse drug reactions
Rosuvastatin, is a widely-used statin for the treatment of hypercholesterolemia and the prevention of cardiovascular diseases. Although rosuvastatin is well tolerated, about 3/10.000 patients can suffer severe myopathy. ...
Ascorbic acid supplementation ameliorates testicular hormonal signaling, sperm production and oxidative stress in male rats exposed to rosuvastatin during pre-puberty
(2019-02-01)
Dyslipidemias are occurring earlier in the population due to the augmentation of obesity. Rosuvastatin reduces cholesterol and triglycerides; however, previous studies have shown that it may affect male reproduction. ...
Effects of subchronic exposure to sibutramine and/or rosuvastatin on reproductive parameters of Wistar rats
(Elsevier B.V., 2016-10-01)