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GABAA receptor and cell membrane potential as functional endpoints in cultured neurons to evaluate chemicals for human acute toxicity
(Pergamon-Elsevier Science Ltd, 2010-02)
Toxicity risk assessment for chemical-induced human health hazards relies mainly on data obtained from animal experimentation, human studies and epidemiology. In vitro testing for acute toxicity based on cytotoxicity assays ...
Wnt-5a Modulates Recycling of Functional GABAA Receptors on Hippocampal Neurons
(2010-06-23)
GABAA receptors (GABAA-Rs) play a significant role in mediating fast synaptic inhibition and it is the main inhibitory receptor in the
CNS. The role of Wnt signaling in coordinating synapse structure and function in the ...
Acute stress or systemic insulin injection increases flunitrazepam sensitive-GABAA receptor density in synaptosomes of chick forebrain: Modulation by systemic epinephrine
(Taylor & Francis Ltd, 2009-06-07)
Interactions between acute stress and systemic insulin and epinephrine on GABAA receptor density in the forebrain were studied. Here, 10 day-old chicks were intraperitoneally injected with insulin, epinephrine or vehicle ...
GABA(A) receptor blockade in dorsomedial and ventromedial nuclei of the hypothalamus evokes panic-like elaborated defensive behaviour followed by innate fear-induced antinociception
(ELSEVIER SCIENCE BV, 2009)
Dysfunction in the hypothalamic GABAergic system has been implicated in panic syndrome in humans. Furthermore, several studies have implicated the hypothalamus in the elaboration of pain modulation. Panic-prone states are ...
Influence of anabolic steroid on anxiety levels in sedentary male rats
(Taylor & Francis LtdAbingdonInglaterra, 2007)