Buscar
Mostrando ítems 21-30 de 82
Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective
(Pergamon-Elsevier Science Ltd, 2016-08)
Enhancement of α7 nicotinic receptor (nAChR) function by positive allosteric modulators (PAMs) is a promising therapeutic strategy to improve cognitive deficits. PAMs have been classified only on the basis of their macroscopic ...
Differential Pharmacological Activity of JN403 between á7 and Muscle Nicotinic Acetylcholine Receptors
(American Chemical Society, 2013-10)
The differential action of the novel agonist JN403 at neuronalα7 and muscle nicotinic receptors (AChRs)was explored by using a combination of functional and structural approaches. Single-channel recordings reveal that JN403 ...
Role of the cys loop and transmembrane domain in the allosteric modulation of alpha 4 beta 2 nicotinic acetylcholine receptors
(2017)
Allosteric modulators of pentameric ligand-gated ion channels are thought to act on elements of the pathways that couple agonist binding to channel gating. Using alpha 4 beta 2 nicotinic acetylcholine receptors and the ...
Tyrosine phosphorylation differentially fine-tunes ionotropic and metabotropic responses of human α7 nicotinic acetylcholine receptor
(Springer Nature Switzerland, 2021-05-24)
The α7 nicotinic acetylcholine receptor is involved in neurological, neurodegenerative, and inflammatory disorders. It operates both as a ligand-gated cationic channel and as a metabotropic receptor in neuronal and ...
5-HT3 Receptor Brain-Type B-Subunits are Differentially Expressed in Heterologous Systems
(American Chemical Society, 2015-05)
Genes for five different 5-HT 3 receptor subunits have been identified. Most of the subunits have multiple isoforms, but two isoforms of the B subunits, brain-type 1 (Br1) and brain-type 2 (Br2) are of particular interest ...
Role of the cys loop and transmembrane domain in the allosteric modulation of α4β2 nicotinic acetylcholine receptors
(American Society for Biochemistry and Molecular Biology Inc., 2017)
© 2017 by The American Society for Biochemistry and Molecular Biology, Inc.Allosteric modulators of pentameric ligand-gated ion channels are thought to act on elements of the pathways that couple agonist binding to channel ...
A new antagonist of caenorhabditis elegans glutamate-activated chloride channels with anthelmintic activity
(Frontiers Media, 2020-08-19)
Nematode parasitosis causes significant mortality and morbidity in humans andconsiderable losses in livestock and domestic animals. The acquisition of resistanceto current anthelmintic drugs has prompted the search for new ...