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Spatial-temporal study of Rab1b dynamics and function at the ER-Golgi interface
(Public Library of Science, 2016-08)
The GTPase Rab1b is involved in ER to Golgi transport, with multiple Rab1b effectors (located at ERES, VTCs and the Golgi complex) being required for its function. In this study, we performed live-cell dual-expression ...
Rab11-Family of Interacting Protein 2 associates with chlamydial inclusions through its Rab-binding domain and promotes bacterial multiplication
(Wiley, 2012-11-01)
Chlamydia trachomatis, an obligate intracellular pathogen, survives within host cells in a special compartment named ‘inclusion’ and takes advantage of host vesicular transport pathways for its growth and replication. Rab ...
Cdk5 regulation of the grab-mediated rab8-rab11 cascade in axon outgrowth
(2017)
Neurons communicate with each other through their axons and dendrites. However, a full characterization of the molecular mechanisms involved in axon and dendrite formation is still incomplete. Neurite outgrowth requires ...
Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis
(Oncotarget, 2016)
Hypoxia, a common condition of the tumor microenvironment, is associated with poor patient prognosis, tumor cell migration, invasion and metastasis. Recent evidence suggests that hypoxia alters endosome dynamics in tumor ...
Coxiella burnetii localizes in a Rab7-labeled compartment with autophagic characteristics
(Amer Soc Microbiology, 2002-10-01)
The obligate intracellular bacterium Coxiella burnetii, the agent of Q fever in humans and of coxiellosis in other animals, survives and replicates within large, acidified, phagolysosome-like vacuoles known to fuse homo- ...
Small GTPases as regulators of cell division
(Landes Bioscience, 2013-09)
The superfamily of small GTPases serves as a signal transducer to regulate a diverse array of cellular functions. The members of this superfamily are structurally and functionally classified into at least 5 groups (Ras, ...
Targeting eukaryotic Rab proteins: a smart strategy for chlamydial survival and replication
(Wiley, 2014-08)
Chlamydia, an obligate intracellular bacterium which passes its entire lifecycle within a membrane-bound vacuole called the inclusion, has evolved a variety of unique strategies to establish an advantageous intracellular ...
Small GTpases in acrosomal exocytosis
(Springer, 2015-01)
Regulated exocytosis employs a conserved molecular machinery in all secretory cells. Soluble N -ethylmaleimide-sensitive factor attachment protein receptor (SNARE) and Rab superfamilies are members of this machinery. Rab ...