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Translation and Silencing in RNA Granules: a Tale of Sand Grains
(Frontiers, 2014-07)
The transcriptome at the synapse consists of thousands of messengers encoding several cellular functions, including a significant number of receptors and ion channels and associated proteins. The concerted translational ...
An essential nuclear protein in trypanosomes is a component of mRNA transcription/export pathway
(Public Library of Science, 2018)
In vivo knockdown of antisense non-coding mitochondrial RNAs by a lentiviral-encoded shRNA inhibits melanoma tumor growth and lung colonization
(Wiley, 2018)
The family of non-coding mitochondrial RNAs (ncmtRNA) is differentially expressed according to proliferative status. Normal proliferating cells express sense (SncmtRNA) and antisense ncmtRNAs (ASncmtRNAs), whereas tumor ...
Fluoxetine induces preventive and complex effects against colon cancer development in epithelial and stromal areas in rats
(ELSEVIER IRELAND LTD, 2011)
Fluoxetine (FIX) is a drug commonly used as antidepressant. However, its effects on tumorigenesis remain controversial. Aiming to evaluate the effects of FIX treatment on early malignant changes, we analyzed serotonin ...
Distrofia Miotónica tipo 1: Fisiopatología y Avances en la Terapia Génica
(2014-12)
La distrofa miotónica tipo 1 (la
enfermedad muscular hereditaria mas
común en el adulto joven) es causada por
una expansión de la tripleta citosina-timinaguanina (CTG), la cual es inestable en las
líneas germinal y ...
Distrofia Miotónica tipo 1: Fisiopatología y Avances en la Terapia Génica
(2014-12)
La distrofa miotónica tipo 1 (la
enfermedad muscular hereditaria mas
común en el adulto joven) es causada por
una expansión de la tripleta citosina-timinaguanina (CTG), la cual es inestable en las
líneas germinal y ...
Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice.
(2020)
Abstract
Background
Hexanucleotide repeat expansions of the G4C2 motif in a non-coding region of the C9ORF72 gene are the most common genetic cause of amyotrophic lateral ...
Efeitos da ingestão de Arthrospira (Spirulina platensis) spp. na etapa de promoção da carcinogênese química de cólon em animais alimentados com hemin
(Universidade Estadual Paulista (Unesp), 2022-02-25)
O risco elevado de desenvolver câncer colorretal (CCR) pode estar associado à hábitos alimentares inadequados, incluindo o consumo elevado de carne vermelha e processada. Evidências sustentam, que o hemin, uma porfirina ...
Exposure to an Environmentally Relevant Phthalate Mixture during Prostate Development Induces MicroRNA Upregulation and Transcriptome Modulation in Rats
(2019-09-01)
Environmental exposure to phthalates during intrauterine development might increase susceptibility to neoplasms in reproductive organs such as the prostate. Although studies have suggested an increase in prostatic lesions ...