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The giardial VPS35 retromer subunit is necessary for multimeric complex assembly and interaction with the Vacuolar protein sorting receptor
(Elsevier, 2013-06)
The retromer is a pentameric protein complex that mediates the retrograde transport of acid hydrolase receptors between endosomes and the trans-Golgi network and is conserved across all eukaryotes. Unlike other eukaryotes, ...
AP1B sorts basolateral proteins in recycling and biosynthetic routes of MDCK cells
(NATL ACAD SCIENCES, 2007)
The epithelial-specific adaptor AP1B sorts basolateral proteins, but the trafficking routes where it performs its sorting role remain controversial. Here, we used an RNAi approach to knock down the medium subunit of AP1B ...
Polarized Traffic of LRP1 Involves AP1B and SNX17 Operating on Y- dependent Sorting Motifs in Different Pathways
(2009)
Low-density lipoprotein receptor-related protein 1 (LRP1) is an endocytic recycling receptor with two cytoplasmic tyrosine-based basolateral sorting signals. Here we show that during biosynthetic trafficking LRP1 uses AP1B ...
Rapid Endocytosis and Vesicle Recycling in Neuroendocrine Cells
(Springer, 2010-11)
Endocytosis is a crucial process for neuroendocrine cells that ensures membrane homeostasis, vesicle recycling, and hormone release reliability. Different endocytic mechanisms have been described in chromaffin cells, such ...
Cholinergic abnormalities, endosomal alterations and up-regulation of nerve growth factor signaling in Niemann-Pick Type C disease
(2012)
Abstract
Background
Neurotrophins and their receptors regulate several aspects of the developing and mature nervous system, including neuronal morphology and survival. ...
The membrane glycoprotein M6a endocytic/recycling pathway involves clathrin-nediated endocytosis and affects neuronal synapses
(Frontiers, 2017)
Abstract: Single point mutations or variations in the expression of the gene encoding the neuronal glycoprotein M6a have been associated with psychiatric disorders such as Alzheimer's disease, depression and schizophrenia. ...
Associations among genotype, clinical phenotype, and intracellular localization of trafficking proteins in ARC syndrome
(WILEY-BLACKWELLHOBOKEN, 2012)
Arthrogryposisrenal dysfunctioncholestasis (ARC) syndrome is a rare autosomal recessive multisystem disorder caused by mutations in vacuolar protein sorting 33 homologue B (VPS33B) and VPS33B interacting protein, ...
MAS1 Receptor Trafficking Involves ERK1/2 Activation Through a β-Arrestin2–Dependent PathwayNovelty and Significance
(Lippincott Williams, 2017-11)
The MAS1 receptor (R) exerts protective effects in the brain, heart, vessels, and kidney. R trafficking plays a critical function in signal termination and propagation and in R resensitization. We examined MAS1R internalization ...
Physiologically induced restructuring of focal adhesions causes mobilization of vinculin by a vesicular endocytic recycling pathway
(Elsevier Science, 2014-12)
In epithelial cells, vinculin is enriched in cell adhesion structures but is in equilibrium with a large cytosolic pool. It is accepted that when cells adhere to the extracellular matrix, a part of the soluble cytosolic ...